Patel, Priya; Robinson, Paula D; Fisher, Brian T; Phillips, Robert; Morgan, Jessica E; Lehrnbecher, Thomas; Kuczynski, Susan; Koenig, Christa; Haeusler, Gabrielle M; Esbenshade, Adam; Elgarten, Caitlin; Duong, Nathan; Diorio, Caroline; Castagnola, Elio; Beauchemin, Melissa P; Ammann, Roland A; Dupuis, L Lee; Sung, Lillian (2024). Guideline for the management of Clostridioides difficile infection in pediatric patients with cancer and hematopoietic cell transplantation recipients: 2024 update. EClinicalMedicine, 72(102604) Elsevier 10.1016/j.eclinm.2024.102604
|
Text
1-s2.0-S2589537024001834-main.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (285kB) | Preview |
Our objective was to update a clinical practice guideline for the prevention and treatment of Clostridioides difficile infection (CDI) in pediatric patients with cancer and hematopoietic cell transplantation recipients. We reconvened an international multi-disciplinary panel. A systematic review of randomized controlled trials (RCTs) for the prevention or treatment of CDI in any population was updated and identified 31 new RCTs. Strong recommendations were made to use either oral metronidazole or oral vancomycin for non-severe CDI treatment, and to use either oral vancomycin or oral fidaxomicin for severe CDI. A strong recommendation that fecal microbiota transplantation should not be routinely used to treat CDI was also made. The panel made two new good practice statements to follow infection control practices including isolation in patients experiencing CDI, and to minimize systemic antibacterial administration where feasible, especially in patients who have experienced CDI.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine |
UniBE Contributor: |
König, Christa |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2589-5370 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
29 Apr 2024 15:46 |
Last Modified: |
30 Apr 2024 02:33 |
Publisher DOI: |
10.1016/j.eclinm.2024.102604 |
PubMed ID: |
38680517 |
Uncontrolled Keywords: |
Clostridioides difficile infection Pediatric oncology Practice guideline Prevention Treatment |
BORIS DOI: |
10.48350/196371 |
URI: |
https://boris.unibe.ch/id/eprint/196371 |
Actions (login required)
 |
Edit item |