Sulicka-Grodzicka, Joanna; Wizner, Barbara; Zdrojewski, Tomasz; Mossakowska, Małgorzata; Puzianowska-Kuźnicka, Monika; Chudek, Jerzy; Więcek, Andrzej; Korkosz, Mariusz; Caiazzo, Elisabetta; Maffia, Pasquale; Siedlinski, Mateusz; Messerli, Franz H.; Guzik, Tomasz J (2024). Sex-specific relationships of inflammatory biomarkers with blood pressure in older adults. GeroScience, 46(5), pp. 4603-4614. Springer 10.1007/s11357-024-01170-8
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Emerging evidence indicates an association between blood pressure and inflammation, yet this relationship remains unclear in older adults, despite the elevated prevalence of hypertension. We investigated the association between blood pressure, high sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and white blood cell (WBC) count in a cohort of 3571 older adults aged 65 and above, and 587 middle-aged participants (55-59 years old). In women aged 65 and above, the relationship between inflammatory markers and blood pressure was consistent, with hs-CRP and WBC emerging as predictors of high blood pressure. For hs-CRP, the adjusted odds ratio (OR) was 1.5 (95% CI, 1.07 to 2.10, P = 0.02), and for WBC, the adjusted OR was 1.41 (95% CI, 1.02 to 1.94, P = 0.04), comparing the highest to the lowest quartiles. In men, only the WBC count was significantly associated with an increased OR for high BP (adjusted OR 1.49, 95% CI, 1.09 to 2.02, P = 0.01) across quartiles. Across the entire study population, in a fully adjusted model, all inflammatory markers were modestly associated with blood pressure levels, while the effect of being over 65 years was the most significant predictor of high blood pressure (OR 1.84, 95% CI, 1.50 to 2.25, P < 0.001). The link between key inflammation markers and blood pressure in older adults varies by sex and biomarker type and may differ from the relationship observed in younger individuals. These relationships are likely to be affected by factors linked to age.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Kardiologie 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Kardiologie |
UniBE Contributor: |
Messerli, Franz |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2509-2723 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
10 May 2024 11:40 |
Last Modified: |
22 Aug 2024 00:13 |
Publisher DOI: |
10.1007/s11357-024-01170-8 |
PubMed ID: |
38720047 |
Uncontrolled Keywords: |
Blood pressure C-reactive protein Interleukin-6 Older adults White blood cells |
BORIS DOI: |
10.48350/196647 |
URI: |
https://boris.unibe.ch/id/eprint/196647 |
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