Morel, Eric; Lingenberg, Alma; Armand, Stéphane; Assal, Frédéric; Allali, Gilles (2024). Normal pressure hydrocephalus and cognitive impairment: The gait phenotype matters too. (In Press). European journal of neurology, e16328. Wiley 10.1111/ene.16328
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Euro_J_of_Neurology_-_2024_-_Morel_-_Normal_pressure_hydrocephalus_and_cognitive_impairment__The_gait_phenotype_matters_too.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (309kB) | Preview |
BACKGROUND AND PURPOSE
Idiopathic normal pressure hydrocephalus (iNPH) is a chronic neurological disease resulting in progressive gait and cognitive disorders. We investigated whether the gait phenotype is associated with the severity of cognitive deficits in iNPH.
METHODS
This retrospective study recruited 88 patients (mean age = 76.18 ± 7.21 years, 42% female). Patients were initially referred for suspicion of iNPH and underwent a comprehensive analysis, including gait analysis and cognitive evaluation.
RESULTS
In this cohort (27% normal gait, 25% frontal gait, 16% parkinsonian gait, 27% other gait abnormalities), patients with parkinsonian and frontal gait had the lowest Mini-Mental State Examination (MMSE) scores and the slowest gait speed. Patients with normal gait had the highest MMSE scores and gait speed. Frontal gait was associated with lower MMSE score, even after adjusting for age, gender, comorbidities, white matter lesions, and education level (β = -0.221 [95% confidence interval (CI) = -3.718 to -0.150], p = 0.034). Normal gait was associated with the best MMSE scores, even after adjusting for the abovementioned variables (β = 0.231 [95% CI = 0.124-3.639], p = 0.036).
CONCLUSIONS
Gait phenotypes among iNPH patients are linked to global cognition as assessed with MMSE.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Morel, Eric |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1468-1331 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
10 May 2024 11:14 |
Last Modified: |
11 May 2024 00:17 |
Publisher DOI: |
10.1111/ene.16328 |
PubMed ID: |
38720477 |
Uncontrolled Keywords: |
clinical evaluation cognition cognitive disorders gait normal pressure hydrocephalus |
BORIS DOI: |
10.48350/196659 |
URI: |
https://boris.unibe.ch/id/eprint/196659 |
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