Social determinants of antidepressant continuation during pregnancy in the USA: findings from the ABCD cohort study.

Dupuis, Marc; Weir, Kristie Rebecca; Vidonscky Lüthold, Renata; Panchaud, Alice; Baggio, Stéphanie (2024). Social determinants of antidepressant continuation during pregnancy in the USA: findings from the ABCD cohort study. (In Press). Archives of Women's Mental Health Springer 10.1007/s00737-024-01470-0

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Patients and healthcare professionals overestimate the risks of using antidepressants during pregnancy. According to current literature, approximately half of people stop taking an anti-depressant medication when they become pregnant. Discontinuing antidepressants during pregnancy increases risks of postnatal relapses. Factors like socioeconomic status, education, and planned pregnancies play a role in the decision to continue antidepressant medication, which can worsen disparities in maternal and child health. Our aim was to identify the sociodemographic factors associated with antidepressant continuation after awareness of pregnancy.


We used representative data from the Adolescent Brain Cognitive Development (ABCD) study that captures maternal medication during pregnancy. We identified women who used antidepressants before awareness of their pregnancy. We calculated crude and adjusted associations between sociodemographic factors and continuation of antidepressant medication during pregnancy. Our model included age, education, ethnicity, first language, household income, living with a partner, having planned the pregnancy, pregnancy duration and smoking during pregnancy.


In total, 199 women continued antidepressants and 100 discontinued. The logistic regressions resulted in only one significant factor: first language. Native English speakers were more likely to continue medication than other mothers (adjusted OR = 14.94, 95% CI = [2.40; 291.45], p = .015).


Language differences were associated with continuation of antidepressants. Non-native English speakers were more likely to discontinue antidepressants, which may lead to health inequities. This finding should be taken into account to reinforce information about the limited risks of antidepressants among people with non-English speaking backgrounds in the USA.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Medical Education > Institute of General Practice and Primary Care (BIHAM)

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Dupuis, Marc, Weir, Kristie Rebecca, Vidonscky Lüthold, Renata, Panchaud Monnat, Alice Elke Martine, Baggio, Stéphanie


600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services








Pubmed Import

Date Deposited:

14 May 2024 10:32

Last Modified:

06 Jun 2024 13:11

Publisher DOI:


PubMed ID:


Additional Information:

Open Access Funding provided by University of Bern.
Panchaud and Baggio contributed equally to this work.

Uncontrolled Keywords:

Antidepressants Continuation Discontinuation Pregnancy Social determinants




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