Histological evaluation of osseointegration between conventional and novel bone-level tapered implants in healed bone-A preclinical study.

Imber, Jean-Claude; Roccuzzo, Andrea; Irani, Delia R; Bellón, Benjamin; Bosshardt, Dieter D; Sculean, Anton; Pippenger, Benjamin E (2024). Histological evaluation of osseointegration between conventional and novel bone-level tapered implants in healed bone-A preclinical study. (In Press). Journal of periodontal research Wiley 10.1111/jre.13285

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AIMS

To histologically compare osseointegration and crestal bone healing between newly introduced tapered, self-cutting bone-level test implants and tapered bone-level control implants in sites with fully healed sites.

METHODS

Sixty-six implants (33 test, 33 control) were placed 1 mm subcrestally in a minipig model and underwent qualitative histologic and quantitative histometric analyses after 3, 6 and 12 weeks of submerged healing. The primary and secondary outcomes were the bone-to-implant contact (BIC) and first bone-to-implant contact (fBIC). Outcomes between the test and control implants were statistically compared.

RESULTS

The BIC values of the test implants were comparable and non-inferior over the time points studied, except for the 12 weeks time point which showed statistically significantly higher BIC values of the test (88.07 ± 5.35%) compared to the control implants (80.88 ± 7.51%) (p = .010). Similarly comparable and non-inferior were the fBIC values, except for the 6-week outcome, which showed statistically higher values for the test (-546.5 ± 450.80 μm) compared to the control implants (-75.7 ± 100.59 μm). fBIC results for the test implants were qualitatively more stable and consistent between test time points.

CONCLUSION

Novel self-cutting bone-level test implants demonstrated superior osseointegration and similar bone levels compared to conventional bone-level implants after a healing period of 12 weeks in healed ridges.

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