Kalimeri, Eleni; Roccuzzo, Andrea; Stähli, Alexandra; Oikonomou, Ilias; Berchtold, Aaron; Sculean, Anton; Kloukos, Dimitrios (2024). Adjunctive use of hyaluronic acid in the treatment of gingival recessions: a systematic review and meta-analysis. Clinical oral investigations, 28(6), p. 329. Springer-Verlag 10.1007/s00784-024-05701-7
|
Text
s00784-024-05701-7.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (941kB) | Preview |
OBJECTIVES
To explore the efficacy of Hyaluronic acid as an adjunctive in treatment of gingival recessions (GR).
MATERIALS AND METHODS
A systematic literature search was performed in several electronic databases, including Medline/ PubMed, Embase, CENTRAL and LILACS. Recession improvement was evaluated through multiple outcome variables. The Cochrane Risk of Bias tool and the ROBINS-I tool were used to assess the quality of the included trials. Weighted Mean Differences (WMDs) and 95% confidence intervals (CIs) between test and control sites were estimated through meta-analysis using a random-effect model for the amount of Relative Root Coverage (RRC).
RESULTS
A total of 3 randomised studies were deemed as eligible for inclusion. Their data were also used for pooling the effect estimates. Overall analysis of RRC (3 studies) presented a WMD of 7.49% (p = 0.42; 95% CIs -10.88, 25.86) in favour of adjunctive use of hyaluronic acid during Coronally Advanced Flap (CAF) technique, although statistical significance was not reached. Statistical heterogeneity was found to be high (I2 = 80%).
CONCLUSIONS
Within their limitations, the present data indicate that the local application of Hyaluronic acid does not lead to additional clinical benefits when used as an adjunctive to the treatment of GR with CAF. However, due to the high heterogeneity among the studies, additional well-designed RCTs are needed to provide further evidence on this clinical indication for the use of Hyaluronic acid.
CLINICAL RELEVANCE
In the frame of the current review, the adjunctive use of Hyaluronic acid does not additionally improve the clinical outcomes obtained during treatment of GR with CAF.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Orthodontics 04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology |
UniBE Contributor: |
Roccuzzo, Andrea, Stähli, Alexandra Beatrice, Sculean, Anton, Kloukos, Dimitrios (B) |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1432-6981 |
Publisher: |
Springer-Verlag |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
22 May 2024 07:46 |
Last Modified: |
23 May 2024 05:52 |
Publisher DOI: |
10.1007/s00784-024-05701-7 |
PubMed ID: |
38771388 |
Uncontrolled Keywords: |
Gingival recession Hyaluronic acid Root coverage |
BORIS DOI: |
10.48350/196959 |
URI: |
https://boris.unibe.ch/id/eprint/196959 |
Actions (login required)
 |
Edit item |