Diffusion-weighted MR spectroscopy of the prostate.

Stamatelatou, Angeliki; Rizzo, Rudy; Simsek, Kadir; van Asten, Jack J A; Heerschap, Arend; Scheenen, Tom; Kreis, Roland (2024). Diffusion-weighted MR spectroscopy of the prostate. (In Press). Magnetic resonance in medicine Wiley 10.1002/mrm.30141

[img]
Preview
Text
Magnetic_Resonance_in_Med_-_2024_-_Stamatelatou_-_Diffusion_weighted_MR_spectroscopy_of_the_prostate.pdf - Published Version
Available under License Creative Commons: Attribution-Noncommercial (CC-BY-NC).

Download (6MB) | Preview

PURPOSE

Prostate tissue has a complex microstructure, mainly composed of epithelial and stromal cells, and of extracellular (acinar-luminal) spaces. Diffusion-weighted MR spectroscopy (DW-MRS) is ideally suited to explore complex microstructure in vivo with metabolites selectively distributed in different subspaces. To date, this technique has been applied to brain and muscle. This study presents the development and pioneering utilization of 1H-DW-MRS in the prostate, accompanied by in vitro studies to support interpretations of in vivo findings.

METHODS

Nine healthy volunteers underwent a prostate MR examination (mean age, 56 years; range, 31-66). Metabolic complexation was studied in vitro using solutions with major compounds found in prostatic fluid of the lumen. DW-MRS was performed at 3 T with a non-water-suppressed single-voxel sequence with metabolite-cycling to concurrently measure metabolite and water signals. The water signal was used in postprocessing as a reference in a motion-compensation scheme. The spectra were fitted simultaneously in the spectral and diffusion-weighting dimensions. Apparent diffusion coefficients (ADCs) were derived by fitting signal decays that were assumed to be mono-exponential for metabolites and biexponential for water.

RESULTS

DW-MRS of the prostate revealed relatively low ADCs for Cho and Cr compounds, aligning with their intracellular location and higher ADCs for citrate and spermine supporting their luminal origin. In vitro assessments of the ADCs of citrate and spermine demonstrated their complex formation and protein binding. Tissue concentrations of MRS-detectable metabolites were as expected for the voxel location.

CONCLUSIONS

This work successfully demonstrates the feasibility of 1H-DW-MRS of the prostate and its potential for providing valuable microstructural information.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Faculty Institutions > sitem Center for Translational Medicine and Biomedical Entrepreneurship
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology > DCR Magnetic Resonance Spectroscopy and Methodology (AMSM)
07 Faculty of Human Sciences > Institute of Psychology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Rizzo, Rudy, Kreis, Roland

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1522-2594

Publisher:

Wiley

Language:

English

Submitter:

Pubmed Import

Date Deposited:

22 May 2024 15:27

Last Modified:

23 May 2024 09:24

Publisher DOI:

10.1002/mrm.30141

PubMed ID:

38775024

Uncontrolled Keywords:

MR spectroscopic imaging (MRSI) diffusion MR spectroscopy molecular complexation multiparametric model fitting prostate proton MR spectroscopy (MRS)

BORIS DOI:

10.48350/196996

URI:

https://boris.unibe.ch/id/eprint/196996

Actions (login required)

Edit item Edit item
Provide Feedback