Kong, Yanyan; Cao, Lei; Wang, Jiao; Zhuang, Junyi; Liu, Yongshan; Bi, Lei; Qiu, Yifan; Hou, Yuyi; Huang, Qi; Xie, Fang; Yang, Yunhao; Shi, Kuangyu; Rominger, Axel Oliver; Guan, Yihui; Jin, Hongjun; Ni, Ruiqing (2024). Increased Cerebral Level of P2X7R in a Tauopathy Mouse Model by PET Using [18F]GSK1482160. ACS chemical neuroscience, 15(11), pp. 2112-2120. American Chemical Society 10.1021/acschemneuro.4c00067
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kong-et-al-2024-increased-cerebral-level-of-p2x7r-in-a-tauopathy-mouse-model-by-pet-using-18f-gsk1482160.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (9MB) | Preview |
Neuroinflammation plays an important role in Alzheimer's disease and primary tauopathies. The aim of the current study was to map [18F]GSK1482160 for imaging of purinergic P2X7R in Alzheimer's disease and primary tauopathy mouse models. Small animal PET was performed using [18F]GSK1482160 in widely used mouse models of Alzheimer's disease (APP/PS1, 5×FAD, and 3×Tg), 4-repeat tauopathy (rTg4510) mice, and age-matched wild-type mice. Increased uptake of [18F]GSK1482160 was observed in the brains of 7-month-old rTg4510 mice compared to wild-type mice and compared to 3-month-old rTg4510 mice. A positive correlation between hippocampal tau [18F]APN-1607 and [18F]GSK1482160 uptake was found in rTg4510 mice. No significant differences in the uptake of [18F]GSK1482160 was observed for APP/PS1 mice, 5×FAD mice, or 3×Tg mice. Immunofluorescence staining further indicated the distribution of P2X7Rs in the brains of 7-month-old rTg4510 mice with accumulation of tau inclusion. These findings provide in vivo imaging evidence for an increased level of P2X7R in the brains of tauopathy mice.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine |
UniBE Contributor: |
Shi, Kuangyu, Rominger, Axel Oliver, Ni, Ruiqing |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1948-7193 |
Publisher: |
American Chemical Society |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
23 May 2024 08:53 |
Last Modified: |
06 Jun 2024 00:16 |
Publisher DOI: |
10.1021/acschemneuro.4c00067 |
PubMed ID: |
38776461 |
Uncontrolled Keywords: |
Alzheimer’s disease P2X7R PET amyloid-β glia tau |
BORIS DOI: |
10.48350/197029 |
URI: |
https://boris.unibe.ch/id/eprint/197029 |
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