Leta, Tesfaye H; Lie, Stein Atle; Fenstad, Anne Marie; Lygre, Stein Håkon L; Lindberg-Larsen, Martin; Pedersen, Alma B; W-Dahl, Annette; Rolfson, Ola; Bülow, Erik; van Steenbergen, Liza N; Nelissen, Rob G H H; Harries, Dylan; de Steiger, Richard; Lutro, Olav; Mäkelä, Keijo; Venäläinen, Mikko S; Willis, Jinny; Wyatt, Michael; Frampton, Chris; Grimberg, Alexander; ... (2024). Periprosthetic Joint Infection After Total Knee Arthroplasty With or Without Antibiotic Bone Cement. JAMA Network Open, 7(5), e2412898. American Medical Association 10.1001/jamanetworkopen.2024.12898
|
Text
leta_2024_oi_240450_1715725940.97332.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (1MB) | Preview |
IMPORTANCE
Despite increased use of antibiotic-loaded bone cement (ALBC) in joint arthroplasty over recent decades, current evidence for prophylactic use of ALBC to reduce risk of periprosthetic joint infection (PJI) is insufficient.
OBJECTIVE
To compare the rate of revision attributed to PJI following primary total knee arthroplasty (TKA) using ALBC vs plain bone cement.
DESIGN, SETTING, AND PARTICIPANTS
This international cohort study used data from 14 national or regional joint arthroplasty registries in Australia, Denmark, Finland, Germany, Italy, New Zealand, Norway, Romania, Sweden, Switzerland, the Netherlands, the UK, and the US. The study included primary TKAs for osteoarthritis registered from January 1, 2010, to December 31, 2020, and followed-up until December 31, 2021. Data analysis was performed from April to September 2023.
EXPOSURE
Primary TKA with ALBC vs plain bone cement.
MAIN OUTCOMES AND MEASURES
The primary outcome was risk of 1-year revision for PJI. Using a distributed data network analysis method, data were harmonized, and a cumulative revision rate was calculated (1 - Kaplan-Meier), and Cox regression analyses were performed within the 10 registries using both cement types. A meta-analysis was then performed to combine all aggregated data and evaluate the risk of 1-year revision for PJI and all causes.
RESULTS
Among 2 168 924 TKAs included, 93% were performed with ALBC. Most TKAs were performed in female patients (59.5%) and patients aged 65 to 74 years (39.9%), fully cemented (92.2%), and in the 2015 to 2020 period (62.5%). All participating registries reported a cumulative 1-year revision rate for PJI of less than 1% following primary TKA with ALBC (range, 0.21%-0.80%) and with plain bone cement (range, 0.23%-0.70%). The meta-analyses based on adjusted Cox regression for 1 917 190 TKAs showed no statistically significant difference at 1 year in risk of revision for PJI (hazard rate ratio, 1.16; 95% CI, 0.89-1.52) or for all causes (hazard rate ratio, 1.12; 95% CI, 0.89-1.40) among TKAs performed with ALBC vs plain bone cement.
CONCLUSIONS AND RELEVANCE
In this study, the risk of revision for PJI was similar between ALBC and plain bone cement following primary TKA. Any additional costs of ALBC and its relative value in reducing revision risk should be considered in the context of the overall health care delivery system.
Item Type: |
Journal Article (Original Article) |
---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
UniBE Contributor: |
Brand, Christian Michael Georg |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
2574-3805 |
Publisher: |
American Medical Association |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
24 May 2024 12:47 |
Last Modified: |
12 Jun 2024 12:53 |
Publisher DOI: |
10.1001/jamanetworkopen.2024.12898 |
PubMed ID: |
38780939 |
BORIS DOI: |
10.48350/197053 |
URI: |
https://boris.unibe.ch/id/eprint/197053 |