Exploration of Rhenium Bisquinoline Tricarbonyl Complexes for their Antibacterial Properties.

Fulgencio, Sofia; Scaccaglia, Mirco; Frei, Angelo (2024). Exploration of Rhenium Bisquinoline Tricarbonyl Complexes for their Antibacterial Properties. ChemBioChem, 25(17), e202400435. Wiley 10.1002/cbic.202400435

[img] Text
ChemBioChem_-_2024_-_Fulgencio_-_Exploration_of_Rhenium_Bisquinoline_Tricarbonyl_Complexes_for_their_Antibacterial.pdf - Accepted Version
Restricted to registered users only until 24 May 2025.
Available under License Publisher holds Copyright.

Download (1MB)

Metal complexes have emerged as a promising source for novel classes of antibacterial agents to combat the rise of antimicrobial resistance around the world. In the exploration of the transition metal chemical space for novel metalloantibiotics, the rhenium tricarbonyl moiety has been identified as a promising scaffold. Here we have prepared eight novel rhenium bisquinoline tricarbonyl complexes and explored their antibacterial properties. Significant activity against both Gram-positive and Gram-negative bacteria was observed. However, all complexes also showed significant toxicity against human cells, putting into question the prospects of this specific rhenium compound class as metalloantibiotics. To better understand their biological effects, we conduct the first mode of action studies on rhenium bisquinoline complexes and show that they are able to form pores through bacterial membranes. Their straight-forward synthesis and tuneability suggests that further optimisation of this compound class could lead to compounds with enhanced bacterial specificity.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP)

UniBE Contributor:

Frei, Angelo

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

1439-7633

Publisher:

Wiley

Language:

English

Submitter:

Pubmed Import

Date Deposited:

27 May 2024 09:42

Last Modified:

03 Sep 2024 00:13

Publisher DOI:

10.1002/cbic.202400435

PubMed ID:

38785033

Uncontrolled Keywords:

Metalloantibiotics Metals in medicine antimicrobial resistance organometallic chemistry rhenium

BORIS DOI:

10.48350/197065

URI:

https://boris.unibe.ch/id/eprint/197065

Actions (login required)

Edit item Edit item
Provide Feedback