Individual cerebellar metabolic connectome in patients with MTLE and NTLE associated with surgical prognosis.

Tang, Yongxiang; Zhu, Haoyue; Xiao, Ling; Li, Rong; Han, Honghao; Tang, Weiting; Liu, Ding; Zhou, Chunyao; Liu, Dingyang; Yang, Zhiquan; Zhou, Luo; Xiao, Bo; Rominger, Axel; Shi, Kuangyu; Hu, Shuo; Feng, Li (2024). Individual cerebellar metabolic connectome in patients with MTLE and NTLE associated with surgical prognosis. European journal of nuclear medicine and molecular imaging, 51(12), pp. 3600-3616. Springer 10.1007/s00259-024-06762-2

Text s00259-024-06762-2.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (4MB)

PURPOSE

This study aimed to comprehensively explore the different metabolic connectivity topological changes in MTLE and NTLE, as well as their association with surgical outcomes.

METHODS

This study enrolled a cohort of patients with intractable MTLE and NTLE. Each individual's metabolic connectome, as determined by Kullback-Leibler divergence similarity estimation for the [18F]FDG PET image, was employed to conduct a comprehensive analysis of the cerebral metabolic network. Alterations in network connectivity were assessed by extracting and evaluating the strength of edge and weighted connectivity. By utilizing these two connectivity strength metrics with the cerebellum, we explored the network properties of connectivity and its association with prognosis in surgical patients.

RESULTS

Both MTLE and NTLE patients exhibited substantial alterations in the connectivity of the metabolic network at the edge and nodal levels (p < 0.01, FDR corrected). The key disparity between MTLE and NTLE was observed in the cerebellum. In MTLE, there was a predominance of increased connectivity strength in the cerebellum. Whereas, a decrease in cerebellar connectivity was identified in NTLE. It was found that in MTLE, higher edge connectivity and weighted connectivity strength in the contralateral cerebellar hemisphere correlated with improved surgical outcomes. Conversely, in NTLE, a higher edge metabolic connectivity strength in the ipsilateral cerebellar hemisphere suggested a worse surgical prognosis.

CONCLUSION

The cerebellum exhibits distinct topological characteristics in the metabolic networks between MTLE and NTLE. The hyper- or hypo-metabolic connectivity in the cerebellum may be a prognostic biomarker of surgical prognosis, which might aid in therapeutic decision-making for TLE individuals.

Interest & Impact

Downloads

0 since deposited on 29 May 2024
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item