Response to Innes and Mattsson: Neospora caninum emerges from the shadow of Toxoplasma gondii

Hemphill, A (2007). Response to Innes and Mattsson: Neospora caninum emerges from the shadow of Toxoplasma gondii. Trends in parasitology, 2(23), pp. 44-5. Oxford: Elsevier Current Trends 10.1016/j.pt.2006.12.007

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It is tempting to extrapolate research findings regarding the intensively studied Toxoplasma gondii to Neospora caninum. This is based on morphological and ultrastructural studies, the molecular phylogeny of both parasites, their wide host ranges in nature, their ability to invade many different cell types in vitro and the occurrence of homologous proteins in both species. However, as Innes and Mattsson point out, T. gondii is the most successful parasite worldwide, whereas N. caninum has a more limited host range. Thus, some of the most challenging questions are: (i) what is T. gondii doing that N. caninum is not doing, or is doing differently, that renders the former so much more successful? And (ii) can some of these features be exploited for the development of interventional tools to limit infection and pathology caused by N. caninum?

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology

UniBE Contributor:

Hemphill, Andrew

ISSN:

1471-4922

Publisher:

Elsevier Current Trends

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:47

Last Modified:

21 Jan 2014 15:05

Publisher DOI:

10.1016/j.pt.2006.12.007

PubMed ID:

17188023

Web of Science ID:

000244396300004

URI:

https://boris.unibe.ch/id/eprint/19724 (FactScience: 2651)

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