A case report of Clarkson's disease: If you don't know it, you'll miss it

Bonadies, Nicolas; Baud, Patricia; Peter, Hans-Jakob; Buergi, Ulrich; Mueller, Beatrice U (2006). A case report of Clarkson's disease: If you don't know it, you'll miss it. European journal of internal medicine, 17(5), pp. 363-5. Roma: Pozzi 10.1016/j.ejim.2005.12.011

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The systemic capillary leak syndrome (SCLS), also known as Clarkson's disease, is a rare disorder characterized by paroxysmal capillary hyperpermeability with a shift of plasma fluid from the intravascular to the interstitial space. A 35-year-old previously healthy woman was admitted with rapidly developing hypovolemic shock syndrome, rhabdomyolysis, and diffuse edema. Laboratory analysis revealed a severe hemoconcentration, renal insufficiency, and paraproteinemia. After exclusion of infection, allergy, burning or drug-induced conditions, the clinical presentation was consistent with the diagnosis of SCLS. Though this is a rare entity, the substantial morbidity and mortality associated with it necessitate the physician's awareness in order to provide timely therapy. This report is meant to enhance awareness of SCLS.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Medical Department Anna Seiler-House

UniBE Contributor:

Bonadies, Nicola; Peter, Hans-Jakob and Müller, Beatrice Ursula

ISSN:

0953-6205

ISBN:

16864014

Publisher:

Pozzi

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:47

Last Modified:

06 Dec 2013 13:42

Publisher DOI:

10.1016/j.ejim.2005.12.011

PubMed ID:

16864014

Web of Science ID:

000242964000013

URI:

https://boris.unibe.ch/id/eprint/19737 (FactScience: 2669)

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