Cardiac Magnetic Resonance Evaluation of LV Remodeling Post-Myocardial Infarction: Prognosis, Monitoring and Trial Endpoints.

Gissler, Mark Colin; Antiochos, Panagiotis; Ge, Yin; Heydari, Bobak; Gräni, Christoph; Kwong, Raymond Y (2024). Cardiac Magnetic Resonance Evaluation of LV Remodeling Post-Myocardial Infarction: Prognosis, Monitoring and Trial Endpoints. (In Press). JACC. Cardiovascular imaging Elsevier 10.1016/j.jcmg.2024.03.012

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Adverse left ventricular remodeling (ALVR) and subsequent heart failure after myocardial infarction (MI) remain a major cause of patient morbidity and mortality worldwide. Overt inflammation has been identified as the common pathway underlying myocardial fibrosis and development of ALVR post-MI. With its ability to simultaneously provide information about cardiac structure, function, perfusion, and tissue characteristics, cardiac magnetic resonance (CMR) is well poised to inform prognosis and guide early surveillance and therapeutics in high-risk cohorts. Further, established and evolving CMR-derived biomarkers may serve as clinical endpoints in prospective trials evaluating the efficacy of novel anti-inflammatory and antifibrotic therapies. This review provides an overview of post-MI ALVR and illustrates how CMR may help clinical adoption of novel therapies via mechanistic or prognostic imaging markers.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Gräni, Christoph

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1876-7591

Publisher:

Elsevier

Language:

English

Submitter:

Pubmed Import

Date Deposited:

04 Jun 2024 14:02

Last Modified:

05 Jun 2024 08:49

Publisher DOI:

10.1016/j.jcmg.2024.03.012

PubMed ID:

38819335

Uncontrolled Keywords:

LV remodeling cardiac magnetic resonance fibrosis heart failure inflammation myocardial infarction

BORIS DOI:

10.48350/197433

URI:

https://boris.unibe.ch/id/eprint/197433

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