Redlich Bossy, Mona; Müller, Daniel R; Niedermoser, Daryl W; Burrer, Achim; Spiller, Tobias R; Vetter, Stefan; Seifritz, Erich; Egger, Stephan T (2024). Impact of psychopathology on day-to-day living in patients with schizophrenia: A network analysis. Comprehensive psychiatry, 133(152501), p. 152501. Elsevier 10.1016/j.comppsych.2024.152501
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Although the relationship between schizophrenia and disability is well established, the association between the symptoms of the disorder and functional domains remains unclear. The current study explored the nuances of the relationship between symptoms and domains of functioning in a sample of 1127 patients with schizophrenia. We assessed the symptoms of schizophrenia with the Positive and Negative Syndrome Scale (PANSS) and psychosocial functioning with the mini-ICF-APP (mini-International Classification of Functioning Rating for Limitations of Activities and Participation in Psychological Disorders). The mean PANSS score was 94.28 (27.20), and the mean mini-ICF-APP score was 25.25 (8.96), both of which are indicative of severe symptom load and impairment. We were able to show a strong relationship and overlap between symptoms and disability in patients with schizophrenia. We identified several symptoms related to functional impairment. Deficits in judgment and abstract thinking contribute to impairment through poor adherence (to routines and compliance with rules) and difficulties in planning and organizing. We believe that in schizophrenia, symptoms and their interactions constitute a disorder beyond any single manifestation. Furthermore, we suggest that cognitive testing and cognitive treatment should become part of the standard of care for patients with schizophrenia.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center 04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy |
UniBE Contributor: |
Müller, Daniel (B) |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0010-440X |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
03 Jun 2024 16:07 |
Last Modified: |
22 Jun 2024 00:15 |
Publisher DOI: |
10.1016/j.comppsych.2024.152501 |
PubMed ID: |
38820645 |
Uncontrolled Keywords: |
Impairment Network analysis Psychopathology Psychosocial functioning Schizophrenia |
BORIS DOI: |
10.48350/197442 |
URI: |
https://boris.unibe.ch/id/eprint/197442 |
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