Liechti, Fabian D; Bijlsma, Merijn W; Brouwer, Matthijs C; van de Beek, Diederik (2024). Effect of the COVID-19 pandemic on clinical characteristics and outcomes of adult pneumococcal meningitis patients - a Dutch prospective nationwide cohort study. (In Press). Infection Springer Nature 10.1007/s15010-024-02305-x
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PURPOSE
To investigate clinical characteristics and outcomes of patients with pneumococcal meningitis during the COVID-19 pandemic.
METHODS
In a Dutch prospective cohort, risk factors and clinical characteristics of pneumococcal meningitis episodes occurring during the COVID-19 pandemic (starting March 2020) were compared with those from baseline and the time afterwards. Outcomes were compared with an age-adjusted logistic regression model.
RESULTS
We included 1,699 patients in 2006-2020, 50 patients in 2020-2021, and 182 patients in 2021-2023. After March 2020 relatively more alcoholism was reported (2006-2020, 6.1%; 2020-2021, 18%; 2021-2023, 9.7%; P = 0.002) and otitis-sinusitis was less frequently reported (2006-2020, 45%; 2020-2021, 22%; 2021-2023, 47%; P = 0.006). Other parameters, i.e. age, sex, symptom duration or initial C-reactive protein level, remained unaffected. Compared to baseline, lumbar punctures were more frequently delayed (on admission day, 2006-2020, 89%; 2020-2021, 74%; 2021-2022, 86%; P = 0.002) and outcomes were worse ('good recovery', 2020-2021, OR 0.5, 95% CI 0.3-0.8).
CONCLUSION
During the COVID-19 pandemic, we observed worse outcomes in patients with pneumococcal meningitis. This may be explained by differing adherence to restrictions according to risk groups or by reduced health care quality.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine |
UniBE Contributor: |
Liechti, Fabian |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1439-0973 |
Publisher: |
Springer Nature |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
04 Jun 2024 10:19 |
Last Modified: |
04 Jun 2024 10:28 |
Publisher DOI: |
10.1007/s15010-024-02305-x |
PubMed ID: |
38831205 |
Uncontrolled Keywords: |
Streptococcus pneumoniae Alcoholism Bacterial meningitis COVID-19 Pneumococcal meningitis Quality of health care |
BORIS DOI: |
10.48350/197533 |
URI: |
https://boris.unibe.ch/id/eprint/197533 |
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