Arterial stiffness assessed by digital volume pulse correlates with comorbidity in patients with ESRD

Sollinger, Daniel; Mohaupt, Markus G; Wilhelm, Albina; Uehlinger, Dominik; Frey, Felix J; Eisenberger, Ute (2006). Arterial stiffness assessed by digital volume pulse correlates with comorbidity in patients with ESRD. American Journal of Kidney Diseases, 48(3), pp. 456-63. Philadelphia, Pa.: W.B. Saunders 10.1053/j.ajkd.2006.05.014

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BACKGROUND: Digital volume pulse (DVP), a noninvasive method for indirect assessment of arterial stiffness, was not tested previously in patients with end-stage renal disease (ESRD). Therefore, we compared the DVP-derived stiffness index (SI(DVP)) with aortic pulse wave velocity (PWV) determined by means of Doppler ultrasonography in 2 groups of patients with ESRD and analyzed the correlation between SI(DVP) and comorbidity. METHODS: Photoplethysmography was performed on the index finger of the dominant hand or the hand from the nonfistula arm in 49 renal transplant (TX) recipients and 48 hemodialysis (HD) patients. Pulse curves were analyzed with computer assistance. Comorbidity was assessed by using an established index. RESULTS: The intrasubject variability of SI(DVP) was 5.7%. SI(DVP) and aortic PWV values correlated significantly (r = 0.66; P = 0.001) in patients with ESRD. SI(DVP) could not be assessed reliably in 25% and 6% of HD patients and TX recipients, respectively. Multivariate regression analyses showed that SI(DVP) increased with age in both HD patients and TX recipients (r = 0.61; P < 0.001) and with systolic blood pressure (r = 0.53; P < 0.025), mean arterial pressure (r = 0.47; P < 0.05), and pulse pressure (r = 0.52; P = 0.02) in TX recipients. Severity of comorbid status was associated highly with individual residuals of age-adjusted SI(DVP) in HD patients and TX recipients (P < 0.001). CONCLUSION: DVP allows the measurement of arterial stiffness in most, but not all, patients with ESRD. SI(DVP) values correlate with comorbidity in HD patients and TX recipients.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology > Centre of Competence for Psychosomatic Medicine
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

UniBE Contributor:

Sollinger, Daniel Florian, Mohaupt, Markus, Uehlinger, Dominik, Frey, Felix (B), Eisenberger, Ute






W.B. Saunders




Markus Georg Mohaupt

Date Deposited:

04 Oct 2013 14:47

Last Modified:

29 Mar 2023 23:32

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URI: (FactScience: 2690)

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