Tran, Fabian; Ruperti-Repilado, Francisco Javier; Haaf, Philip; Ayala, Pedro Lopez; Greutmann, Matthias; Schwerzmann, Markus; Bouchardy, Judith; Gabriel, Harald; Stambach, Dominik; Schwitter, Juerg; Wustmann, Kerstin; Freese, Michael; Mueller, Christian; Tobler, Daniel (2024). NT-proBNP in systemic right ventricles: a new cutoff level for risk stratification? (In Press). Revista española de cardiología - English Edition Elsevier Doyma 10.1016/j.rec.2024.05.006
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INTRODUCTION AND OBJECTIVES
The role of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in the risk prediction of patients with systemic right ventricles (sRV) is not well defined. The aim of this study was to analyze the prognostic value of NT-proBNP in patients with an sRV.
METHODS
The prognostic value of NT-proBNP was assessed in 98 patients from the SERVE trial. We used an adjusted Cox proportional hazards model, survival analysis, and c-statistics. The composite primary outcome was the occurrence of clinically relevant arrhythmia, heart failure, or death. Correlations between baseline NT-proBNP values and biventricular volumes and function were assessed by adjusted linear regression models.
RESULTS
The median age [interquartile range] at baseline was 39 [32-48] years and 32% were women. The median NT-proBNP was 238 [137-429] ng/L. Baseline NT-proBNP concentrations were significantly higher among the 20 (20%) patients developing the combined primary outcome compared with those who did not (816 [194-1094] vs 205 [122-357]; P = .003). In patients with NT-proBNP concentrations > 75th percentile (> 429 ng/L), we found an exponential increase in the sex- and age-adjusted hazard ratio for the primary outcome. The prognostic value of NT-proBNP was comparable to right ventricular ejection fraction and peak oxygen uptake on exercise testing (c-statistic: 0.71, 0.72 and 0.71, respectively).
CONCLUSIONS
In patients with sRVs, NT-proBNP concentrations correlate with sRV volumes and function and may serve as a simple tool for predicting adverse outcomes.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology |
UniBE Contributor: |
Schwerzmann, Markus |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1885-5857 |
Publisher: |
Elsevier Doyma |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
12 Jun 2024 08:20 |
Last Modified: |
12 Jun 2024 15:33 |
Publisher DOI: |
10.1016/j.rec.2024.05.006 |
PubMed ID: |
38844073 |
Uncontrolled Keywords: |
Biomarcadores Biomarkers Cardiología Cardiopatías congénitas del adulto Congenital heart disease Heart Failure Insuficiencia cardiaca Transposition of the great arteries |
BORIS DOI: |
10.48350/197654 |
URI: |
https://boris.unibe.ch/id/eprint/197654 |
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