Abraham, Rinu; Waldman-Levi, Amiya; Barrera, Marissa A; Bogaardt, Hans; Golan, Daniel; Bergmann, Catherine; Sullivan, Cynthia; Wilken, Jeffrey; Zarif, Myassar; Bumstead, Barbara; Buhse, MariJean; Covey, Thomas J; Doniger, Glen M; Penner, Iris-Katharina; Hancock, Laura M; Morrow, Sarah A; Giroux, Erin; Gudesblatt, Mark (2024). Exploring the relationship between manual dexterity and cognition in people with multiple sclerosis: 9-hole peg and multiple cognitive functions. Multiple sclerosis and related disorders, 88, p. 105696. Elsevier 10.1016/j.msard.2024.105696
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AIM AND RATIONALE
Problems with manual dexterity and cognition impact the everyday performance of people with multiple sclerosis (PwMS). Accumulated findings point to the relationship between deficits in manual dexterity and auditory domains of cognition with a lack of evidence on visuospatial and verbal aspects of cognitive functioning. Therefore, this study explores the relationship between manual dexterity and cognition in a cohort of PwMS.
METHOD
This cross-sectional study collected data from 63 PwMS aged 22 to 55 through a convenient sampling method. Participants were diagnosed with relapsing-remitting multiple sclerosis (RRMS). Cognition was measured using a multi-domain computerized cognitive testing, NeuroTrax, and manual dexterity was measured using a 9-hole peg assessment. Spearman correlation was used to identify the correlation among cognition subtests as well as with manual dexterity. Linear regression analysis was also conducted to identify whether manual dexterity predicts cognitive functioning.
RESULTS
A significant negative correlation was found between 9-hole peg scores and global cognitive scores (GCS), r = -0.34, p = 006. The manual dexterity scores were also shown to predict GCS, R2= 0.165, p = 0.001.
CONCLUSION
Manual dexterity was found to not only predict cognitive dysfunction but was also associated with multiple cognitive domains. Understanding the relationship between manual dexterity and cognition and the inferred progression of deficits can assist clinicians to provide interventions at earlier stages of disease progression to potentially increase daily functioning and quality of life (QoL).
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Penner, Iris-Katharina |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2211-0356 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
11 Jun 2024 09:41 |
Last Modified: |
29 Jul 2024 00:14 |
Publisher DOI: |
10.1016/j.msard.2024.105696 |
PubMed ID: |
38850796 |
Uncontrolled Keywords: |
Cognition Manual dexterity Multiple sclerosis |
BORIS DOI: |
10.48350/197698 |
URI: |
https://boris.unibe.ch/id/eprint/197698 |
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