Bio-Inspired Micro- and Nano-Scale Surface Features Produced by Femtosecond Laser-Texturing Enhance TiZr-Implant Osseointegration.

Lackington, William Arthur; Bellon, Benjamin; Guimond, Stefanie; Schweizer, Peter; Cancellieri, Claudia; Ambeza, Antoine; Chopard-Lallier, Anne-Lise; Pippenger, Benjamin; Armutlulu, Andac; Maeder, Xavier; Schmutz, Patrik; Rottmar, Markus (2024). Bio-Inspired Micro- and Nano-Scale Surface Features Produced by Femtosecond Laser-Texturing Enhance TiZr-Implant Osseointegration. (In Press). Advanced healthcare materials, e2400810. Wiley 10.1002/adhm.202400810

Text Adv_Healthcare_Materials_-_2024_-_Lackington_-_Bio_Inspired_Micro__and_Nano_Scale_Surface_Features_Produced_by_Femtosecond.pdf - Accepted Version Restricted to registered users only until 10 June 2025. Available under License Publisher holds Copyright. Download (2MB) | Request a copy

Surface design plays a critical role in determining the integration of dental implants with bone tissue. Femtosecond laser-texturing has emerged as a breakthrough technology offering excellent uniformity and reproducibility in implant surface features. However, when compared to state-of-the-art sandblasted and acid-etched surfaces, laser-textured surface designs typically underperform in terms of osseointegration. This study investigated the capacity of a bio-inspired femtosecond laser-textured surface design to enhance osseointegration compared to state-of-the-art sandblasted & acid-etched surfaces. Laser-texturing facilitates the production of an organized trabeculae-like microarchitecture with superimposed nano-scale laser-induced periodic surface structures on both 2D and 3D samples of titanium-zirconium-alloy. Following a boiling treatment to modify the surface chemistry, improving wettability to a contact angle of 10°, laser-textured surfaces enhance fibrin network formation when in contact with human whole blood, comparable to state-of-the-art surfaces. In vitro experiments demonstrate that laser-textured surfaces significantly outperform state-of-the-art surfaces with a 2.5-fold higher level of mineralization by bone progenitor cells after 28 days of culture. Furthermore, in vivo evaluations reveal superior biomechanical integration of laser-textured surfaces after 28 days of implantation. Notably, during abiological pull-out tests, laser-textured surfaces exhibit comparable performance, suggesting that the observed enhanced osseointegration is primarily driven by the biological response to the surface. This article is protected by copyright. All rights reserved.

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