Kummer, Isabelle; Lüthi, Andreas; Klingler, Gabriela; Andereggen, Lukas; Urman, Richard D; Luedi, Markus M; Stieger, Andrea (2024). Adjuvant Analgesics in Acute Pain - Evaluation of Efficacy. Current pain and headache reports, 28(9), pp. 843-852. Springer 10.1007/s11916-024-01276-w
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PURPOSE OF THE REVIEW
Acute postoperative pain impacts a significant number of patients and is associated with various complications, such as a higher occurrence of chronic postsurgical pain as well as increased morbidity and mortality.
RECENT FINDINGS
Opioids are often used to manage severe pain, but they come with serious adverse effects, such as sedation, respiratory depression, postoperative nausea and vomiting, and impaired bowel function. Therefore, most enhanced recovery after surgery protocols promote multimodal analgesia, which includes adjuvant analgesics, to provide optimal pain control. In this article, we aim to offer a comprehensive review of the contemporary literature on adjuvant analgesics in the management of acute pain, especially in the perioperative setting. Adjuvant analgesics have proven efficacy in treating postoperative pain and reducing need for opioids. While ketamine is an established option for opioid-dependent patients, magnesium and α2-agonists have, in addition to their analgetic effect, the potential to attenuate hemodynamic responses, which make them especially useful in painful laparoscopic procedures. Furthermore, α2-agonists and dexamethasone can extend the analgesic effect of regional anesthesia techniques. However, findings for lidocaine remain inconclusive.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Neurochirurgie 04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy |
UniBE Contributor: |
Andereggen, Lukas, Lüdi, Markus |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1534-3081 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
18 Jun 2024 14:25 |
Last Modified: |
23 Sep 2024 00:13 |
Publisher DOI: |
10.1007/s11916-024-01276-w |
PubMed ID: |
38865074 |
Uncontrolled Keywords: |
Adjuvant analgesics Co-analgesics Dexamethasone Intravenous lidocaine Ketamine Magnesium Perioperative pain management α2-agonists |
BORIS DOI: |
10.48350/197795 |
URI: |
https://boris.unibe.ch/id/eprint/197795 |
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