Non-invasive monitoring of renal oxygenation using BOLD-MRI: a reproducibility study

Simon Zoula, Sonia; Hofmann, Lucie; Giger, Andreas; Vogt, Bruno; Vock, Peter; Frey, Felix Julius; Boesch, Chris (2006). Non-invasive monitoring of renal oxygenation using BOLD-MRI: a reproducibility study. NMR in biomedicine, 19(1), pp. 84-9. London: Wiley Interscience 10.1002/nbm.1004

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Blood oxygenation level-dependent (BOLD) MRI was shown to allow non-invasive observation of renal oxygenation in humans. However, clinical applications of this type of functional MRI of the kidney are still limited, most likely because of difficulties in obtaining reproducible and reliable information. The aim of this study was to evaluate the reproducibility and robustness of a BOLD method applied to the kidneys and to identify systematic physiological changes potentially influencing the renal oxygenation of healthy volunteers. To measure the BOLD effect, a modified multi-echo data image combination (MEDIC) sequence was used to acquire 12 T2*-weighted images within a single breath-hold. Three identical measurements were performed on three axial and three coronal slices of right and left kidneys in 18 volunteers. The mean R2* (1/T2*) values determined in medulla and cortex showed no significant differences over three repetitions and low intra-subject coefficients of variation (CV) (3 and 4% in medulla and cortex, respectively). The average R2* values were higher in the medulla (16.15 +/- 0.11) than in the cortex (11.69 +/- 0.18) (P < 0.001). Only a minor influence of slice orientation was observed. Mean R2* values were slightly higher (3%) in the left than in the right kidney (P < 0.001). Differences between volunteers were identified (P < 0.001). Part of these differences was attributable to age-dependent R2* values, since these values increased with age when medulla (P < 0.001, r = 0.67) or cortex (P < 0.020, r = 0.42) were considered. Thus, BOLD measurements in the kidney are highly reproducible and robust. The results allow one to identify the known cortico-medullary gradient of oxygenation evidenced by the gradient of R2* values and suggest that medulla is more hypoxic in older than younger individuals. BOLD-MRI is therefore a useful tool to study sequentially and non-invasively regional oxygenation of human kidneys.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology > DCR Magnetic Resonance Spectroscopy and Methodology (AMSM)

UniBE Contributor:

Simon Zoula, Sonia; Hofmann, Lucie; Vogt, Bruno; Vock, Peter; Frey, Felix Julius and Bösch, Christoph Hans

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0952-3480

ISBN:

16411163

Publisher:

Wiley Interscience

Language:

English

Submitter:

Lucie Hofmann

Date Deposited:

04 Oct 2013 14:47

Last Modified:

17 Mar 2015 21:47

Publisher DOI:

10.1002/nbm.1004

PubMed ID:

16411163

Web of Science ID:

000235678000010

URI:

https://boris.unibe.ch/id/eprint/19780 (FactScience: 2723)

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