Merki-Feld, Gabriele; Dietrich, Hanna; Imesch, Patrick; Gantenbein, Andreas R; Sandor, Peter; Schankin, Christoph J (2024). Investigating migraine phenotype and dynamics in women with endometriosis: an observational pilot study. Acta neurologica Belgica, 124(4), pp. 1263-1271. Springer 10.1007/s13760-024-02484-2
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INTRODUCTION
Migraine and endometriosis are chronic disabling pain conditions. There is evidence for a shared genetic background. Migraine phenotype and course in patients with the comorbidity are insufficient investigated. Both conditions can be treated with progestins.
METHODS
For this observational study we included women with migraine and endometriosis, visiting our clinic from 2015 to 2021. We collected available information from charts and complemented these data by a structured phone interview to collect more specific information on migraine and the course of both diseases.
RESULTS
From 344 patients fulfilling the inclusion criteria, 94 suffered from both, endometriosis and migraine. Migraine with aura was reported by 41% of the patients and was associated with earlier onset of migraine (age < 17 years (OR 6.54) and with a history of medication overuse headache (OR 9.9, CI 1.6-59.4). Present monthly migraine frequency (1.5 ± 2.6) was significantly lower than five years before the interview (2.9 ± 4.64). There was a correlation between medication overuse headache and use of analgesics more than 3 days/months for dysmenorrhoea (p < 0.03). ASRM endometriosis score was not associated with migraine characteristics.
CONCLUSIONS
We conclude that the comorbidity of endometriosis is highly linked to migraine with aura. Migraine onset in these patients was earlier. Further studies are needed to explore, if the observed decrease in migraine frequency can be attributed to recent endometriosis surgery and to understand if early diagnosis and treatment of both conditions may contribute to improve the course of both conditions. Trial registration BASEC Nr. 2021-00285.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Schankin, Christoph Josef |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2240-2993 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
19 Jun 2024 08:40 |
Last Modified: |
25 Jul 2024 00:15 |
Publisher DOI: |
10.1007/s13760-024-02484-2 |
PubMed ID: |
38878131 |
Uncontrolled Keywords: |
Aura Dysmenorrhea Endometriosis Migraine |
BORIS DOI: |
10.48350/197860 |
URI: |
https://boris.unibe.ch/id/eprint/197860 |
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