Magaton, Isotta Martha; Arecco, Luca; Mariamidze, Elene; Jankovic, Kristina; Stana, Mihaela; Buzzatti, Giulia; Trevisan, Lucia; Scavone, Graziana; Ottonello, Silvia; Fregatti, Piero; Massarotti, Claudia; von Wolff, Michael; Lambertini, Matteo (2024). Fertility and Pregnancy-Related Issues in Young BRCA Carriers With Breast Cancer. Breast cancer, 18(11782234241261429) 10.1177/11782234241261429
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Approximately 10% to 15% of breast cancer cases in young women are diagnosed in patients harbouring germline (g) pathogenic or likely pathogenic variants (PVs) in the BReast CAncer 1 (BRCA1) or BReast CAncer 2 (BRCA2) genes. Preclinical and clinical studies showed a potential negative effect of germline BRCA1/2 (gBRCA1/2) PVs on ovarian reserve and reproductive potential, even before starting anticancer therapies. The aim of this article is to summarize the current literature on the fertility potential of young gBRCA1/2 PVs carriers with breast cancer and the risk of gonadotoxicity associated with anticancer treatments. Moreover, we describe the available evidence on the efficacy of fertility preservation techniques in young gBRCA1/2 PVs carriers and the safety data on having a pregnancy after breast cancer treatment.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology |
UniBE Contributor: |
Magaton, Isotta Martha |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1178-2234 |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
17 Jun 2024 16:29 |
Last Modified: |
18 Jun 2024 04:09 |
Publisher DOI: |
10.1177/11782234241261429 |
PubMed ID: |
38882447 |
Uncontrolled Keywords: |
Germline BRCA1/2 pathogenic variants anti-Müllerian hormone fertility oncofertility pregnancy |
BORIS DOI: |
10.48350/197891 |
URI: |
https://boris.unibe.ch/id/eprint/197891 |
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