Skiba, Rafal M; Chinchani, Abhijit M; Menon, Mahesh; Lepage, Martin; Lavigne, Katie M; Malla, Ashok; Joober, Ridha; Goldberg, Joel O; Heinrichs, R Walter; Castle, David J; Burns, Amy; Best, Michael W; Rossell, Susan L; Walther, Sebastian; Woodward, Todd S (2024). Overlap between individual differences in cognition and symptoms of schizophrenia. Schizophrenia research, 270, pp. 220-228. Elsevier 10.1016/j.schres.2024.06.010
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BACKGROUND
Neurocognitive impairment is a core feature of schizophrenia spectrum disorders (SSDs), and the relationship between cognition and symptoms in SSDs has been widely researched. Negative symptoms are related to a wide range of cognitive impairments; however, the aspects of negative symptoms that underpin this relationship have yet to be specified.
STUDY DESIGN
We used iterative Constrained Principal Component Analysis (iCPCA) to explore the relationship between 18 cognitive measures (including processing speed, attention, working, spatial and verbal memory and executive functions) and 46 symptoms in schizophrenia at the individual item level while minimizing the risk of Type I errors. ICPCA was conducted on a sample of SSD patients in the early stages of psychiatric treatment (n = 121) to determine the components of cognition overlapping with symptoms measured by the Scale for the Assessment of Negative Symptoms (SANS) and the Scale for the Assessment of Positive Symptoms (SAPS).
RESULTS
We found that a verbal memory component was associated with items from SANS and SAPS related to impoverished and disorganized emotional communication, language, and thought. In contrast, a working memory component was associated with SANS items related to motor system impoverishment.
CONCLUSIONS
The iCPCA allowed us to explore the associations between individual items, optimized to understand the overlap between symptoms and cognition. The specific symptoms linked to verbal and working memory impairments imply distinct brain networks, which further investigation may lead to our deeper understanding of the illness and the development of treatment methods.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center |
UniBE Contributor: |
Walther, Sebastian |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1573-2509 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
27 Jun 2024 10:42 |
Last Modified: |
13 Aug 2024 00:15 |
Publisher DOI: |
10.1016/j.schres.2024.06.010 |
PubMed ID: |
38924940 |
Uncontrolled Keywords: |
Cognition Disorganized and impoverished communication Motor impoverishment Psychotic symptoms Schizophrenia Verbal and working memory |
BORIS DOI: |
10.48350/198156 |
URI: |
https://boris.unibe.ch/id/eprint/198156 |
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