Metzincins, including matrix metalloproteinases and meprin, in kidney transplantation

Berthier, Céline; Marti, Hans-Peter (2006). Metzincins, including matrix metalloproteinases and meprin, in kidney transplantation. Swiss medical weekly, 136(49-50), pp. 789-94. Muttenz: EMH Schweizerischer Ärzteverlag

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Chronic allograft nephropathy, including chronic rejection, remains one of the major causes of renal allograft failure. Amongst other mediators, metzincins, such as matrix metalloproteinases (MMP), direct extracellular matrix metabolism and cell proliferation. Thus, we hypothesized, that these proteolytic enzymes are differentially regulated in chronic renal transplant rejection in rats and in human renal allograft nephropathy. Our studies demonstrated on the experimental level and in humans an overall up-regulation of MMP, tissue inhibitors of metalloproteinases (TIMP) and related enzymes as a result of rejection processes. Thus, metzincins may represent novel markers and therapeutic targets with respect to renal allograft rejection.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

UniBE Contributor:

Marti, Hans-Peter

ISSN:

1424-7860

ISBN:

17299656

Publisher:

EMH Schweizerischer Ärzteverlag

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:47

Last Modified:

06 Dec 2013 13:42

PubMed ID:

17299656

Web of Science ID:

000243544500002

URI:

https://boris.unibe.ch/id/eprint/19816 (FactScience: 2794)

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