Intradural cystic schwannomas of the spine: A case-based systematic review of an unusual tumor.

Terrapon, Alexis Paul Romain; Stienen, Martin N; Veeravagu, Anand; Fehlings, Michael; Bozinov, Oliver; Hejrati, Nader (2024). Intradural cystic schwannomas of the spine: A case-based systematic review of an unusual tumor. Brain and Spine, 4(102843) Elsevier 10.1016/j.bas.2024.102843

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INTRODUCTION

Cystic schwannomas have only been reported in a few case reports/series. As a result, they may be misdiagnosed and a standardized management approach remains challenging to establish.

RESEARCH QUESTION

The aim of this study was to compile all reported cases of cystic schwannomas and analyze the perioperative course based on a systematic review of the literature with an additional two cases from the authors' experience.

MATERIAL AND METHODS

We conducted a search of MEDLINE and CENTRAL databases for spinal intradural extramedullary cystic schwannomas, in accordance to the PRISMA statement. All title/abstracts were screened, and a full-text review of the remaining articles was conducted. The results were compiled in tables and summarized using means and standard deviation (SD), median and interquartile range, and percentage and 95% confidence intervals.

RESULTS

We identified 263 articles, of which 35, which reported 54 cases, were included. Including our case-reports (n = 56), patients had a mean age of 47.7 years (SD ± 13.0 years) at presentation, 57% were males, and most lesions were lumbar (43%). The most common symptoms were pain (82%) and muscle weakness (68%) with 84% of patients showing neurological findings. 70% of patients showed a complete relief of symptoms after surgery and 96% reported improvement. Only four complications were reported.

DISCUSSION AND CONCLUSION

Schwannomas should be considered in the differential diagnosis of intradural extramedullary cystic lesions. Patients typically present with subacute to chronic pain and/or neurologic changes. Surgical resection is the primary therapeutic modality and usually has a good to excellent outcome.

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