Allam, A; Camoni, N; Cirio, S; Salerno, C; Campus, G; Cagetti, M G (2024). Developmental defects of enamel in childhood cancer survivors: A systematic review and meta-analysis. (In Press). European journal of paediatric dentistry Ariesdue 10.23804/ejpd.2024.2256
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AIM
The present systematic review and meta-analysis (Prospero registration number: CRD42023472016) aims to assess the prevalence of developmental defects of enamel (DDEs), qualitatively and/or quantitatively, in childhood cancer survivors (CCS) and evaluate, when possible, these data in comparison with those found in healthy children.
METHODS
Three electronic databases (PubMed, Embase, Scopus) were searched from January 2003 to January 2024 for studies reporting on DDEs in children with a mean age not exceeding 16 years at the time of the study who underwent antineoplastic therapy. The ROBINS-I and the Joanna Briggs Institute (JBI) tools were used to assess the risk of bias. Included studies with comparable outcomes underwent random effects models meta-analysis using Stata®18.
CONCLUSION
CCS showed a higher prevalence of DDEs, both qualitative and quantitative, compared to healthy children. The meta- analysis showed higher odds of developing qualitative defects over quantitative defects in CCS. Conclusions regarding the association between the type of therapy administered, age of therapy initiation, and prevalence of DDEs could not be drawn due to insufficient data. A lack of a standardized method of detecting enamel defects posed a challenge in the qualitative and quantitative analysis.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Preventive, Restorative and Pediatric Dentistry 04 Faculty of Medicine > School of Dental Medicine |
Graduate School: |
Graduate School for Health Sciences (GHS) |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1591-996X |
Publisher: |
Ariesdue |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
17 Jul 2024 07:58 |
Last Modified: |
17 Jul 2024 08:08 |
Publisher DOI: |
10.23804/ejpd.2024.2256 |
PubMed ID: |
38990089 |
BORIS DOI: |
10.48350/198937 |
URI: |
https://boris.unibe.ch/id/eprint/198937 |
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