Is There an Opportunity to De-Escalate Treatments in Selected Patients with Metastatic Hormone-Sensitive Prostate Cancer?

Gómez-Aparicio, María Antonia; López-Campos, Fernando; Buchser, David; Lazo, Antonio; Willisch, Patricia; Ocanto, Abrahams; Sargos, Paul; Shelan, Mohamed; Couñago, Felipe (2024). Is There an Opportunity to De-Escalate Treatments in Selected Patients with Metastatic Hormone-Sensitive Prostate Cancer? Cancers, 16(13) MDPI AG 10.3390/cancers16132331

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The treatment landscape for metastatic hormone-sensitive prostate cancer continues to evolve, with systemic treatment being the mainstay of current treatment. Prognostic and predictive factors such as tumour volume and disease presentation have been studied to assess responses to different treatments. Intensification and de-escalation strategies arouse great interest, so several trials are being developed to further personalize the therapy in these populations. Is there an optimal sequence and a possible option to de-intensify treatment in selected patients with a favourable profile? This and other goals will be the subject of this review.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Shelan, Mohamed

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2072-6694

Publisher:

MDPI AG

Language:

English

Submitter:

Pubmed Import

Date Deposited:

16 Jul 2024 12:24

Last Modified:

17 Jul 2024 13:25

Publisher DOI:

10.3390/cancers16132331

PubMed ID:

39001393

Uncontrolled Keywords:

androgen receptor signalling inhibitors de-intensification metastatic hormone-sensitive prostate cancer treatment intensification

BORIS DOI:

10.48350/198984

URI:

https://boris.unibe.ch/id/eprint/198984

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