Hippocampal network activity forecasts epileptic seizures.

Khambhati, Ankit N; Chang, Edward F; Baud, Maxime O; Rao, Vikram R (2024). Hippocampal network activity forecasts epileptic seizures. (In Press). Nature medicine Nature Publishing Group 10.1038/s41591-024-03149-6

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Seizures in people with epilepsy were long thought to occur at random, but recent methods for seizure forecasting enable estimation of the likelihood of seizure occurrence over short horizons. These methods rely on days-long cyclical patterns of brain electrical activity and other physiological variables that determine seizure likelihood and that require measurement through long-term, multimodal recordings. In this retrospective cohort study of 15 adults with bitemporal epilepsy who had a device that provides chronic intracranial recordings, functional connectivity of hippocampal networks fluctuated in multiday cycles with patterns that mirrored cycles of seizure likelihood. A functional connectivity biomarker of seizure likelihood derived from 90-s recordings of background hippocampal activity generalized across individuals and forecasted 24-h seizure likelihood as accurately as cycle-based models requiring months-long baseline recordings. Larger, prospective studies are needed to validate this approach, but our results have the potential to make reliable seizure forecasts accessible to more people with epilepsy.

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