Tournier, Alexander L; Bonamin, Leoni V; Buchheim-Schmidt, Susann; Cartwright, Steven; Dombrowsky, Christoph; Doesburg, Paul; Holandino, Carla; Kokornaczyk, Maria Olga; van de Kraats, Everine B; López-Carvallo, Jesús Antonio; Nandy, Papiya; Mazón-Suástegui, José Manuel; Mirzajani, Fateme; Poitevin, Bernard; Scherr, Claudia; Thieves, Karin; Würtenberger, Sandra; Baumgartner, Stephan (2024). Scientific guidelines for preclinical research on potentised preparations manufactured according to current pharmacopoeias-the PrePoP guidelines. Journal of Integrative Medicine, 22(5), pp. 533-544. Science Press (China) 10.1016/j.joim.2024.06.005
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OBJECTIVE
Pharmacopoeias regulate the manufacture of potentised pharmaceutical preparations used in different branches of complementary and integrative medicine. The physicochemical properties and biological activity of these preparations are often investigated in preclinical research, yet no guidelines for experimental research currently exist in this area. The present PrePoP guidelines aim to provide recommendations to promote high-quality, statistically sound, and reproducible preclinical research on potentised preparations.
METHODS
Input was gathered from researchers nominated by the relevant scientific societies using a simplified Delphi consensus approach covering the most relevant aspects of basic research methodology in the field including appropriate controls, sample preparation and handling, and statistics. After three rounds of feedback, a consensus was finally reached on the most important aspects and considerations for conducting high-quality research on potentised preparations.
RESULTS
We present a series of recommendations on a range of topics including experimental controls, system stability, blinding and randomisation, environmental influences, and procedures for the preparation of potentised samples and controls, and we address some specific challenges of this research field.
CONCLUSION
This expert consensus process resulted in a robust set of methodological guidelines for research on potentised preparations and provides a valuable framework that will inform and improve the quality of subsequent research in this emerging field.
PLEASE CITE THIS ARTICLE AS
Tournier AL, Bonamin LV, Buchheim-Schmidt S, Cartwright S, Dombrowsky C, Doesburg P, Holandino C, Kokornaczyk MO, van de Kraats EB, López-Carvallo JA, Nandy P, Mazón-Suástegui JM, Mirzajani F, Poitevin B, Scherr C, Thieves K, Würtenberger S, Baumgartner S. Scientific guidelines for preclinical research on potentised preparations manufactured according to current pharmacopoeias-the PrePoP guidelines. J Integr Med. 2024; Epub ahead of print.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Medical Education > Institute of Complementary and Integrative Medicine (IKIM) |
UniBE Contributor: |
Tournier, Alexander, Dombrowsky, Christoph, Kokornaczyk, Maria Olga, Baumgartner, Stephan |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2095-4964 |
Publisher: |
Science Press (China) |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
17 Jul 2024 09:34 |
Last Modified: |
01 Oct 2024 00:14 |
Publisher DOI: |
10.1016/j.joim.2024.06.005 |
PubMed ID: |
39013752 |
Uncontrolled Keywords: |
Basic research Complementary and integrative medicine Fundamental research Potentisation Potentised preparations Research guidelines |
BORIS DOI: |
10.48350/199052 |
URI: |
https://boris.unibe.ch/id/eprint/199052 |
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