Crespo Pimentel, Bernardo; Kuchukhidze, Giorgi; Xiao, Fenglai; Caciagli, Lorenzo; Höfler, Julia; Rainer, Lucas; Kronbichler, Martin; Vollmar, Christian; Duncan, John S; Trinka, Eugen; Koepp, Matthias; Wandschneider, Britta (2024). Sodium valproate is associated with cortical thinning of disease-specific areas in juvenile myoclonic epilepsy. (In Press). Journal of neurology, neurosurgery, and psychiatry BMJ Publishing Group 10.1136/jnnp-2024-333703
![[img]](https://boris.unibe.ch/style/images/fileicons/text.png) |
Text
jnnp-2024-333703.full.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (631kB) | Request a copy |
BACKGROUND
Juvenile myoclonic epilepsy (JME) is associated with cortical thinning of the motor areas. The relative contribution of antiseizure medication to cortical thickness is unknown. We aimed to investigate how valproate influences the cortical morphology of JME.
METHODS
In this cross-sectional study, individuals with JME with and without valproate, with temporal lobe epilepsy (TLE) with valproate and controls were selected through propensity score matching. Participants underwent T1-weighted brain imaging and vertex-wise calculation of cortical thickness.
RESULTS
We matched 36 individuals with JME on valproate with 36 individuals with JME without valproate, 36 controls and 19 individuals with TLE on valproate. JME on valproate showed thinning of the precentral gyri (left and right, p<0.001) compared with controls and thinning of the left precentral gyrus when compared with JME not on valproate (p<0.01) or to TLE on valproate (p<0.001). Valproate dose correlated negatively with the thickness of the precentral gyri, postcentral gyri and superior frontal gyrus in JME (left and right p<0.0001), but not in TLE.
CONCLUSIONS
Valproate was associated with JME-specific and dose-dependent thinning of the cortical motor regions. This suggests that valproate is a key modulator of cortical morphology in JME, an effect that may underlie its high efficacy in this syndrome.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Caciagli, Lorenzo |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1468-330X |
Publisher: |
BMJ Publishing Group |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
24 Jul 2024 09:50 |
Last Modified: |
24 Jul 2024 09:59 |
Publisher DOI: |
10.1136/jnnp-2024-333703 |
PubMed ID: |
39043568 |
Uncontrolled Keywords: |
EPILEPSY IMAGE ANALYSIS MRI |
BORIS DOI: |
10.48350/199170 |
URI: |
https://boris.unibe.ch/id/eprint/199170 |
Actions (login required)
 |
Edit item |