Halkidis, Konstantine; Lämmle, Bernhard; Zheng, X Long (2024). The history of thrombotic thrombocytopenic purpura research: a narrative review. Annals of blood, 9 AME Publishing Company 10.21037/aob-23-46
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BACKGROUND AND OBJECTIVE
Thrombotic thrombocytopenic purpura (TTP) is a rare but debilitating thrombotic microangiopathy that results from severe deficiency of the enzyme ADAMTS13. The disorder was first described in the early 20th century, but the pathophysiology of the disease has only been elucidated in the past three decades. In this narrative review, we will summarize the milestone moments in the history of TTP research and discovery.
METHODS
We searched literature using PubMed from 1924 to 2023 using the following free text searches: "thrombotic thrombocytopenic purpura", "Moschcowitz disease", and "thrombotic microangiopathy". We found 6,917 peer-reviewed articles and sorted through these for relevant literature pertinent to the review. A total of 46 articles were included for review and the remainder were excluded.
KEY CONTENT AND FINDINGS
The history of TTP research was reviewed, with a sampling of major events in the evolution of the understanding of the pathophysiology and treatment of the disease discussed here. There remains much to be learned about the nature of the disease in order to develop more specific and less harmful treatments.
CONCLUSIONS
An overview of the major discoveries that have led to our current understanding of TTP reveals the results of collaboration of multiple groups of physicians and scientists through the past century, with additional breakthroughs likely to occur in the future because of that same collaborative spirit.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory |
UniBE Contributor: |
Lämmle, Bernhard |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2521-361X |
Publisher: |
AME Publishing Company |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
29 Jul 2024 10:12 |
Last Modified: |
29 Jul 2024 10:12 |
Publisher DOI: |
10.21037/aob-23-46 |
PubMed ID: |
39049905 |
Uncontrolled Keywords: |
Thrombotic thrombocytopenic purpura (TTP) therapeutic plasma exchange thrombotic microangiopathy von Willebrand factor (VWF) |
BORIS DOI: |
10.48350/199308 |
URI: |
https://boris.unibe.ch/id/eprint/199308 |
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