Shao, Kai; Hu, Xiaochen; Kleineidam, Luca; Stark, Melina; Altenstein, Slawek; Amthauer, Holger; Boecker, Henning; Buchert, Ralph; Buerger, Katharina; Butryn, Michaela; Cai, Yanning; Cai, Yue; Cosma, Nicoleta Carmen; Chen, Guanqun; Chen, Zhigeng; Daamen, Marcel; Drzezga, Alexander; Düzel, Emrah; Essler, Markus; Ewers, Michael; ... (2024). Amyloid and SCD jointly predict cognitive decline across Chinese and German cohorts. (In Press). Alzheimer's & dementia Elsevier 10.1002/alz.14119
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Alzheimer_s_Dementia_-_2024_-_Shao_-_Amyloid_and_SCD_jointly_predict_cognitive_decline_across_Chinese_and_German_cohorts.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (770kB) | Preview |
INTRODUCTION
Subjective cognitive decline (SCD) in amyloid-positive (Aβ+) individuals was proposed as a clinical indicator of Stage 2 in the Alzheimer's disease (AD) continuum, but this requires further validation across cultures, measures, and recruitment strategies.
METHODS
Eight hundred twenty-one participants from SILCODE and DELCODE cohorts, including normal controls (NC) and individuals with SCD recruited from the community or from memory clinics, underwent neuropsychological assessments over up to 6 years. Amyloid positivity was derived from positron emission tomography or plasma biomarkers. Global cognitive change was analyzed using linear mixed-effects models.
RESULTS
In the combined and stratified cohorts, Aβ+ participants with SCD showed steeper cognitive decline or diminished practice effects compared with NC or Aβ- participants with SCD. These findings were confirmed using different operationalizations of SCD and amyloid positivity, and across different SCD recruitment settings.
DISCUSSION
Aβ+ individuals with SCD in German and Chinese populations showed greater global cognitive decline and could be targeted for interventional trials.
HIGHLIGHTS
SCD in amyloid-positive (Aβ+) participants predicts a steeper cognitive decline. This finding does not rely on specific SCD or amyloid operationalization. This finding is not specific to SCD patients recruited from memory clinics. This finding is valid in both German and Chinese populations. Aβ+ older adults with SCD could be a target population for interventional trials.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine |
UniBE Contributor: |
Rominger, Axel Oliver |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1552-5279 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
30 Jul 2024 09:30 |
Last Modified: |
30 Jul 2024 09:39 |
Publisher DOI: |
10.1002/alz.14119 |
PubMed ID: |
39072956 |
Uncontrolled Keywords: |
PET Stage 2 Alzheimer's disease amyloid pathology cognitive decline cross‐cultural study longitudinal design plasma Aβ42/40 ratio subjective cognitive decline |
BORIS DOI: |
10.48350/199370 |
URI: |
https://boris.unibe.ch/id/eprint/199370 |
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