Schanne, Daniel H; Alder, Dominik U; Lippmann, Jana; Aebersold, Daniel M; Elicin, Olgun (2024). Effect of dose to parotid ducts on Sticky Saliva and Xerostomia in radiotherapy of head and neck squamous cell carcinoma. Radiation oncology, 19(104) BioMed Central 10.1186/s13014-024-02495-6
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BACKGROUND
Radiotherapy (RT) in head and neck squamous cell cancer (HNSCC) often leads to sticky saliva and xerostomia (SSX). Dose sparing of salivary glands (SG) reduces occurrence of SSX but few studies investigated the relationship between RT dose to SG substructures and SSX. We therefore investigated this hypothesis, focusing on the parotid duct (PD).
METHODS
Retrospective data was collected from 99 HNSCC patients treated at our center with (chemo-)radiotherapy (CRT). PD and other organs-at-risk (OAR) were (re-)contoured and DVHs were generated without re-planning. SSX was graded according to CTCAE v.4.03 and evaluated at acute, subacute, and two late timepoints.
RESULTS
Most patients presented with loco-regionally advanced disease. In 47% of patients, up-front neck dissection preceded CRT. Weighted mean dose was 28.6 Gy for bilateral parotid glands (PG), and 32.0 Gy for PD. Acute SSX presented as grades 0 (35.3%), I (41.4%), II (21.2%) and III (2.0%). There was no association of OARs and SSX ≥ grade 2 in univariable logistic regression (LR). Multivariable LR showed statistically significant relationship of acute SSX with: PG weighted mean dose (OR 0.84, p = 0.004), contralateral PG mean dose (OR 1.14, p = 0.02) and contralateral PD planning OAR (PD PRV) mean dose (OR 1.84, p = 0.03).
CONCLUSIONS
There was an association of acute SSX with dose exposure of PD PRV in multivariable regression, only. Due to statistical uncertainties and the retrospective nature of this analysis, further studies are required to confirm or reject the hypothesis.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology |
Graduate School: |
Graduate School for Health Sciences (GHS) |
UniBE Contributor: |
Schanne, Daniel Hendrik, Lippmann, Jana, Aebersold, Daniel Matthias, Eliçin, Olgun |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1748-717X |
Publisher: |
BioMed Central |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
05 Aug 2024 15:01 |
Last Modified: |
06 Aug 2024 08:22 |
Publisher DOI: |
10.1186/s13014-024-02495-6 |
PubMed ID: |
39095864 |
Uncontrolled Keywords: |
Head and neck Parotid duct Parotid gland Squamous cell carcinoma Xerostomia |
BORIS DOI: |
10.48350/199461 |
URI: |
https://boris.unibe.ch/id/eprint/199461 |
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