Hamza, Tasnim; Schwarzer, Guido; Salanti, Georgia (2024). crossnma: An R package to synthesize cross-design evidence and cross-format data using network meta-analysis and network meta-regression. BMC Medical research methodology, 24(169) BioMed Central 10.1186/s12874-023-02130-0
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BACKGROUND
Although aggregate data (AD) from randomised clinical trials (RCTs) are used in the majority of network meta-analyses (NMAs), other study designs (e.g., cohort studies and other non-randomised studies, NRS) can be informative about relative treatment effects. The individual participant data (IPD) of the study, when available, are preferred to AD for adjusting for important participant characteristics and to better handle heterogeneity and inconsistency in the network.
RESULTS
We developed the R package crossnma to perform cross-format (IPD and AD) and cross-design (RCT and NRS) NMA and network meta-regression (NMR). The models are implemented as Bayesian three-level hierarchical models using Just Another Gibbs Sampler (JAGS) software within the R environment. The R package crossnma includes functions to automatically create the JAGS model, reformat the data (based on user input), assess convergence and summarize the results. We demonstrate the workflow within crossnma by using a network of six trials comparing four treatments.
CONCLUSIONS
The R package crossnma enables the user to perform NMA and NMR with different data types in a Bayesian framework and facilitates the inclusion of all types of evidence recognising differences in risk of bias.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
Graduate School: |
Graduate School for Health Sciences (GHS) |
UniBE Contributor: |
Hamza, Tasnim A. A., Salanti, Georgia |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
1471-2288 |
Publisher: |
BioMed Central |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
06 Aug 2024 09:19 |
Last Modified: |
06 Aug 2024 09:28 |
Publisher DOI: |
10.1186/s12874-023-02130-0 |
PubMed ID: |
39103781 |
Uncontrolled Keywords: |
Network meta-analysis Network meta-regression Observational studies R package Real-world evidence Risk of bias |
BORIS DOI: |
10.48350/199508 |
URI: |
https://boris.unibe.ch/id/eprint/199508 |
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