Paschaei, Nusha; Müller, Wolf-Dieter; Schmidt, Franziska; Hüsker, Katrin; von Baehr, Volker; Pandis, Nikolaos; Jost-Brinkmann, Paul-Georg; Bartzela, Theodosia (2024). Unveiling the Role of Metal Ion Concentration versus Immune Sensitization in Orthodontic Patients-A Long-Term Prospective Evaluation. Journal of clinical medicine, 13(15) MDPI 10.3390/jcm13154545
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Background: This longitudinal prospective study aimed to assess orthodontic patients' immune system response to metal ion release in saliva. Methods: Thirty adult patients (18-35 years) were equally divided into three groups: groups at the end (G1) and beginning (G2) of multibracket appliances (MBA) treatment and a non-treated control group (G3). Participants were evaluated at four timepoints within 21 days, with saliva samples being analyzed for metal ion concentrations and blood for the lymphocyte transformation test (LTT). Results: There were no significant differences between groups or timepoints for saliva. LTT analyses revealed hypersensitivity in one-third of all patients and 50% of G2 for nickel, with three developing sensitizations after MBA insertion. All nickel-sensitized patients exhibited varying elevated saliva nickel concentrations. The most nickel-sensitized patients had low ion saliva loads. In borderline nickel-sensitization cases, saliva ion concentrations were up to 20 times higher than the reference. Hypersensitivity to palladium, gold, and mercury was also observed. Conclusions: These findings indicate that increased MBA ion release was not inherently linked to the immune response (Type-IV sensitization), as reactions occurred even with ion levels below thresholds. This underlines the need for a comprehensive evaluation of the immune response to metal ion release in orthodontic patients.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Orthodontics |
UniBE Contributor: |
Pandis, Nikolaos |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2077-0383 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
12 Aug 2024 14:32 |
Last Modified: |
12 Aug 2024 14:41 |
Publisher DOI: |
10.3390/jcm13154545 |
PubMed ID: |
39124811 |
Uncontrolled Keywords: |
ICP-MS analysis corrosion fixed orthodontic appliance immune system in vivo ion release lymphocyte transformation test multibracket orthodontics |
BORIS DOI: |
10.48350/199622 |
URI: |
https://boris.unibe.ch/id/eprint/199622 |
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