Wrzosek, Marcin; Banasik, Aleksandra; Czerwik, Adriana; Olszewska, Agnieszka; Płonek, Marta; Stein, Veronika (2024). Use of sedation-awakening electroencephalography in dogs with epilepsy. Journal of veterinary internal medicine, 38(5), pp. 2578-2589. Wiley 10.1111/jvim.17153
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Veterinary_Internal_Medicne_-_2024_-_Wrzosek_-_Use_of_sedation_awakening_electroencephalography_in_dogs_with_epilepsy.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (3MB) | Preview |
BACKGROUND
Electroencephalography (EEG) recording protocols have been standardized for humans. Although the utilization of techniques in veterinary medicine is increasing, a standard protocol has not yet been established.
HYPOTHESIS
Assessment of a sedation-awakening EEG protocol in dogs.
ANIMALS
Electroencephalography examination was performed in a research colony of 6 nonepileptic dogs (control [C]) and 12 dogs with epilepsy admitted to the clinic because of the epileptic seizures.
METHODS
It was a prospective study with retrospective control. Dogs with epilepsy were divided into 2 equal groups, wherein EEG acquisition was performed using a "sedation" protocol (IE-S, n = 6) and a "sedation-awakening" protocol (IE-SA, n = 6). All animals were sedated using medetomidine. In IE-SA group, sedation was reversed 5 minutes after commencing the EEG recording by injecting atipamezole IM. Type of background activity (BGA) and presence of EEG-defined epileptiform discharges (EDs) were evaluated blindly. Statistical significance was set at P > 0.05.
RESULTS
Epileptiform discharges were found in 1 of 6 of the dogs in group C, 4 of 6 of the dogs in IE-S group, and 5 of 6 of the dogs in IE-SA group. A significantly greater number of EDs (spikes, P = .0109; polyspikes, P = .0109; sharp waves, P = .01) were detected in Phase 2 in animals subjected to the "sedation-awakening" protocol, whereas there was no statistically significant greater number of discharges in sedated animals.
CONCLUSIONS AND CLINICAL IMPORTANCE
A "sedation-awakening" EEG protocol could be of value for ambulatory use if repeated EEG recordings and monitoring of epilepsy in dogs is needed.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Neurology |
UniBE Contributor: |
Stein, Veronika Maria |
Subjects: |
600 Technology > 630 Agriculture |
ISSN: |
1939-1676 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
13 Aug 2024 09:04 |
Last Modified: |
26 Sep 2024 00:15 |
Publisher DOI: |
10.1111/jvim.17153 |
PubMed ID: |
39133769 |
Uncontrolled Keywords: |
ambulatory EEG canine electroencephalography canine epilepsy diagnosis epilepsy paroxysmal sedation seizure |
BORIS DOI: |
10.48350/199654 |
URI: |
https://boris.unibe.ch/id/eprint/199654 |
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