Electrographic seizures during low-current thalamic deep brain stimulation in mice.

Flores, Francisco J; Betta, Isabella Dalla; Tauber, John; Schreier, David R.; Stephen, Emily P; Wilson, Matthew A; Brown, Emery N (2024). Electrographic seizures during low-current thalamic deep brain stimulation in mice. (In Press). Brain stimulation, 17(5), pp. 975-979. Elsevier 10.1016/j.brs.2024.08.002

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BACKGROUND

Deep brain stimulation of central thalamus (CT-DBS) has potential for modulating states of consciousness, but it can also trigger electrographic seizures, including poly-spike-wave trains (PSWT).

OBJECTIVES

To report the probability of inducing PSWTs during CT-DBS in awake, freely-moving mice.

METHODS

Mice were implanted with electrodes to deliver unilateral and bilateral CT-DBS at different frequencies while recording EEG. We titrated stimulation current by gradually increasing it at each frequency until a PSWT appeared. Subsequent stimulations to test arousal modulation were performed at the current one step below the current that caused a PSWT during titration.

RESULTS

In 2.21% of the test stimulations (10 out of 12 mice), CT-DBS caused PSWTs at currents lower than the titrated current, at currents as low as 20 μA.

CONCLUSION

Our study found a small but significant probability of inducing PSWTs even after titration and at relatively low currents. EEG should be closely monitored for electrographic seizures when performing CT-DBS in both research and clinical settings.

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5 Citations in Web of Science ®
6 Citations in Scopus

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