Reduced atrial connexin43 expression after pediatric heart surgery

Pavlovic, Mladen; Schaller, André; Ammann, Roland A; Sanz, Javier; Pfammatter, Jean-Pierre; Carrel, Thierry; Berdat, Pascal; Gallati, Sabina (2006). Reduced atrial connexin43 expression after pediatric heart surgery. Biochemical and biophysical research communications, 342(1), pp. 310-5. Orlando, Fla.: Academic Press 10.1016/j.bbrc.2006.01.146

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Myocardial dysfunction and arrhythmias may be induced by congenital heart defects, but also be the result of heart surgery with cardiopulmonary bypass (CPB), potentially caused by differential expression of connexin40 (Cx40) and connexin43 (Cx43). In 16 pediatric patients undergoing corrective heart surgery, connexin mRNA expression was studied in volume overloaded (VO group, n=8) and not overloaded (NO group, n=8) right atrial myocardium, excised before and after CPB. Additionally, in eight of these patients ventricular specimens were investigated. The atrial Cx43 expression decreased during CPB, which was restricted to the VO group (p=0.008). In contrast, atrial Cx40 mRNA did not change during CPB. In ventricular myocardium compared to atrial mRNA levels, Cx40 was lower (p=0.006) and Cx43 higher (p=0.017) expressed, without significant change during CPB. This study revealed a significant influence of CPB and the underlying heart defect on Cx43 expression.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery

UniBE Contributor:

Pavlovic, Mladen; Schaller, André; Ammann, Roland; Pfammatter, Jean-Pierre; Carrel, Thierry; Berdat, Pascal and Gallati, Sabina

ISSN:

0006-291X

ISBN:

16480955

Publisher:

Academic Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:48

Last Modified:

06 Dec 2013 13:42

Publisher DOI:

10.1016/j.bbrc.2006.01.146

PubMed ID:

16480955

Web of Science ID:

000235793800042

URI:

https://boris.unibe.ch/id/eprint/19973 (FactScience: 3052)

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