The therapy of pre-school wheeze: appropriate and fair?

Chauliac, E S; Silverman, M; Zwahlen, M; Strippoli, M-P F; Brooke, A M; Kuehni, And C E (2006). The therapy of pre-school wheeze: appropriate and fair? Pediatric pulmonology, 41(9), 829-38.. Hoboken, N.J.: Wiley-Blackwell 10.1002/ppul.20450

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The current study aimed to assess prevalence and distribution of use of asthma medication for wheeze in pre-school children in the community. We sent a postal questionnaire to the parents of a random population-based sample of 4,277 UK children aged 1-5 years; 3,410 participated (children of south Asian decent were deliberately over-represented). During the previous 12 months, 18% of the children were reported to have received bronchodilators, 8% inhaled corticosteroids (ICS) and 3% oral corticosteroids. Among current wheezers these proportions were 55%, 25%, and 12%, respectively. Use of ICS increased with reported severity of wheeze, but did not reach 60% even in the most severe category. In contrast, 42% of children receiving ICS reported no or very infrequent recent wheeze. Among children with the episodic viral wheeze phenotype, 17% received ICS compared with 40% among multiple-trigger wheezers. Use of ICS by current wheezers was less common in children of South Asian ethnicity and in girls. Although a high proportion of pre-school children in the community used asthma inhalers, treatment seemed to be insufficiently adjusted to severity or phenotype of wheeze, with relative under-treatment of severe wheeze with ICS, especially in girls and South Asian children, but apparent over-treatment of mild and episodic viral wheeze and chronic cough.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Chauliac, Emmanuelle; Zwahlen, Marcel and Strippoli, Marie-Pierre










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Date Deposited:

04 Oct 2013 14:48

Last Modified:

17 Mar 2015 21:48

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URI: (FactScience: 3183)

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