Evaluation of p24-based antiretroviral treatment monitoring in pediatric HIV-1 infection: prediction of the CD4+ T-cell changes between consecutive visits

Brinkhof, Martin W G; Böni, Jürg; Steiner, Felicitas; Tomasik, Zuzana; Nadal, David; Schüpbach, Jörg (2006). Evaluation of p24-based antiretroviral treatment monitoring in pediatric HIV-1 infection: prediction of the CD4+ T-cell changes between consecutive visits. Journal of acquired immune deficiency syndromes JAIDS, 41(5), pp. 557-562. Philadelphia, Pa.: Lippincott Williams & Wilkins 10.1097/01.qai.0000209824.77784.2c

[img] Text
Brinkhof JAcquirImmuneDeficSyndr 2006.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (145kB) | Request a copy

Worldwide, 700,000 infants are infected annually by HIV-1, most of them in resource-limited settings. Care for these children requires simple, inexpensive tests. We have evaluated HIV-1 p24 antigen for antiretroviral treatment (ART) monitoring in children. p24 by boosted enzyme-linked immunosorbent assay of heated plasma and HIV-1 RNA were measured prospectively in 24 HIV-1-infected children receiving ART. p24 and HIV-1 RNA concentrations and their changes between consecutive visits were related to the respective CD4+ changes. Age at study entry was 7.6 years; follow-up was 47.2 months, yielding 18 visits at an interval of 2.8 months (medians). There were 399 complete visit data sets and 375 interval data sets. Controlling for variation between individuals, there was a positive relationship between concentrations of HIV-1 RNA and p24 (P < 0.0001). While controlling for initial CD4+ count, age, sex, days since start of ART, and days between visits, the relative change in CD4+ count between 2 successive visits was negatively related to the corresponding relative change in HIV-1 RNA (P = 0.009), but not to the initial HIV-1 RNA concentration (P = 0.94). Similarly, we found a negative relationship with the relative change in p24 over the interval (P < 0.0001), whereas the initial p24 concentration showed a trend (P = 0.08). Statistical support for the p24 model and the HIV-1 RNA model was similar. p24 may be an accurate low-cost alternative to monitor ART in pediatric HIV-1 infection.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine

UniBE Contributor:

Brinkhof, Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0894-9255

ISBN:

16652029

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:48

Last Modified:

11 Sep 2017 19:52

Publisher DOI:

10.1097/01.qai.0000209824.77784.2c

PubMed ID:

16652029

Web of Science ID:

000236747600003

BORIS DOI:

10.7892/boris.20077

URI:

https://boris.unibe.ch/id/eprint/20077 (FactScience: 3195)

Actions (login required)

Edit item Edit item
Provide Feedback