Impact of percutaneous patent foramen ovale closure on migraine course

Schwerzmann, Markus; Meier, Bernhard (2010). Impact of percutaneous patent foramen ovale closure on migraine course. Interventional cardiology, 2(2), pp. 177-187. Future Medicine 10.2217/ica.10.6

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Migraine is a neurological disorder characterized by an increased individual susceptibility to respond to certain triggers by a propagating wave of neuronal depolarization that culminates in typical migraine headaches. Patients with a patent foramen ovale or any kind of right-to-left shunt are more likely to have migraine; and patients with migraine with aura are more likely to have a patent foramen ovale than patients without migraine. Nonrandomized reports of patent foramen ovale closure in divers, in patients with paradoxical embolism and in migraine patients with ischemic brain lesions have shown an impressive reduction in migraine headaches during follow-up. To date, the only double-blind, randomized controlled trial with a sham procedure in the control arm failed to show any benefit, probably owing to inadequate patient selection and maybe because of a high residual shunt rate. Two other randomized trials continue to enroll patients with migraine with aura and drug-refractory headaches and their results are awaited.

Item Type:

Journal Article (Further Contribution)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Schwerzmann, Markus and Meier, Bernhard


600 Technology > 610 Medicine & health




Future Medicine




Factscience Import

Date Deposited:

04 Oct 2013 14:11

Last Modified:

08 Jun 2016 10:21

Publisher DOI:


URI: (FactScience: 204164)

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