The mammary gland vasculature revisited

Andres, Anne-Catherine; Djonov, Valentin (2010). The mammary gland vasculature revisited. Journal of mammary gland biology and neoplasia, 15(3), pp. 319-28. New York, N.Y.: Springer 10.1007/s10911-010-9186-9

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Concomitant with the extensive growth and differentiation of the mammary epithelium during pregnancy and lactation, and epithelial involution after weaning, the vasculature of the mammary gland undergoes repeated cycles of expansion and regression. Vascular expansion is effected by sprouting angiogenesis, intussusception and conceivably also vasculogenesis. The capacity of the epithelial cells to stimulate vascular growth and differentiation is dependent on the constellation of systemic and local hormones and growth factors as well as the changing demands for oxygenation and nutrient supply. This results in the release of angiogenic factors which stimulate endothelial cell growth and regulate vascular architecture. In contrast to the angiogenic phase of the mammary gland cycle, little is known about the control of vascular regression although this would possibly offer new insights into therapeutic possibilities against breast cancer. In this review we summarize knowledge regarding the mechanisms regulating the vasculature of the mammary gland and delineate the importance of the vasculature in the attainment of organ function. In addition, we discuss the angiogenic mechanisms observed during mammary carcinogenesis and their consequences for breast cancer therapy.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Tiefenau Hospital (discontinued) > Forschungsgruppe Biologie und Karzinogenese der Brustdrüse (discontinued)
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy

UniBE Contributor:

Andres, Anne Catherine and Djonov, Valentin

ISSN:

1083-3021

Publisher:

Springer

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:11

Last Modified:

08 Mar 2019 11:07

Publisher DOI:

10.1007/s10911-010-9186-9

PubMed ID:

20706777

Web of Science ID:

000281973100005

BORIS DOI:

10.7892/boris.2018

URI:

https://boris.unibe.ch/id/eprint/2018 (FactScience: 204166)

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