Coronary optical frequency domain imaging (OFDI) for in vivo evaluation of stent healing: comparison with light and electron microscopy

Templin, Christian; Meyer, Martin; Müller, Maja Franziska; Djonov, Valentin; Hlushchuk, Ruslan; Dimova, Ivanka; Flueckiger, Stefanie; Kronen, Peter; Sidler, Michele; Klein, Karina; Nicholls, Flora; Ghadri, Jelena-Rima; Weber, Klaus; Paunovic, Dragica; Corti, Roberto; Hoerstrup, Simon P; Lüscher, Thomas F; Landmesser, Ulf (2010). Coronary optical frequency domain imaging (OFDI) for in vivo evaluation of stent healing: comparison with light and electron microscopy. European Heart Journal, 31(14), pp. 1792-801. Oxford: Oxford University Press 10.1093/eurheartj/ehq168

Full text not available from this repository. (Request a copy)

Coronary late stent thrombosis, a rare but devastating complication, remains an important concern in particular with the increasing use of drug-eluting stents. Notably, pathological studies have indicated that the proportion of uncovered coronary stent struts represents the best morphometric predictor of late stent thrombosis. Intracoronary optical frequency domain imaging (OFDI), a novel second-generation optical coherence tomography (OCT)-derived imaging method, may allow rapid imaging for the detection of coronary stent strut coverage with a markedly higher precision when compared with intravascular ultrasound, due to a microscopic resolution (axial approximately 10-20 microm), and at a substantially increased speed of image acquisition when compared with first-generation time-domain OCT. However, a histological validation of coronary OFDI for the evaluation of stent strut coverage in vivo is urgently needed. Hence, the present study was designed to evaluate the capacity of coronary OFDI by electron (SEM) and light microscopy (LM) analysis to detect and evaluate stent strut coverage in a porcine model.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy

UniBE Contributor:

Djonov, Valentin Georgiev and Hlushchuk, Ruslan


600 Technology > 610 Medicine & health




Oxford University Press




Factscience Import

Date Deposited:

04 Oct 2013 14:11

Last Modified:

31 Dec 2020 07:42

Publisher DOI:


PubMed ID:


Web of Science ID:


URI: (FactScience: 204168)

Actions (login required)

Edit item Edit item
Provide Feedback