Coronary optical frequency domain imaging (OFDI) for in vivo evaluation of stent healing: comparison with light and electron microscopy

Templin, Christian; Meyer, Martin; Müller, Maja Franziska; Djonov, Valentin; Hlushchuk, Ruslan; Dimova, Ivanka; Flueckiger, Stefanie; Kronen, Peter; Sidler, Michele; Klein, Karina; Nicholls, Flora; Ghadri, Jelena-Rima; Weber, Klaus; Paunovic, Dragica; Corti, Roberto; Hoerstrup, Simon P; Lüscher, Thomas F; Landmesser, Ulf (2010). Coronary optical frequency domain imaging (OFDI) for in vivo evaluation of stent healing: comparison with light and electron microscopy. European Heart Journal, 31(14), pp. 1792-801. Oxford: Oxford University Press 10.1093/eurheartj/ehq168

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Coronary late stent thrombosis, a rare but devastating complication, remains an important concern in particular with the increasing use of drug-eluting stents. Notably, pathological studies have indicated that the proportion of uncovered coronary stent struts represents the best morphometric predictor of late stent thrombosis. Intracoronary optical frequency domain imaging (OFDI), a novel second-generation optical coherence tomography (OCT)-derived imaging method, may allow rapid imaging for the detection of coronary stent strut coverage with a markedly higher precision when compared with intravascular ultrasound, due to a microscopic resolution (axial approximately 10-20 microm), and at a substantially increased speed of image acquisition when compared with first-generation time-domain OCT. However, a histological validation of coronary OFDI for the evaluation of stent strut coverage in vivo is urgently needed. Hence, the present study was designed to evaluate the capacity of coronary OFDI by electron (SEM) and light microscopy (LM) analysis to detect and evaluate stent strut coverage in a porcine model.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy

UniBE Contributor:

Djonov, Valentin and Hlushchuk, Ruslan

ISSN:

0195-668X

Publisher:

Oxford University Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:11

Last Modified:

06 Mar 2014 22:32

Publisher DOI:

10.1093/eurheartj/ehq168

PubMed ID:

20525979

Web of Science ID:

000280015700024

URI:

https://boris.unibe.ch/id/eprint/2020 (FactScience: 204168)

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