Chronic rhinoviral infection in lung transplant recipients

Kaiser, Laurent; Aubert, John-David; Pache, Jean-Claude; Deffernez, Christelle; Rochat, Thierry; Garbino, Jorge; Wunderli, Werner; Meylan, Pascal; Yerly, Sabine; Perrin, Luc; Letovanec, Igor; Nicod, Laurent; Tapparel, Caroline; Soccal, Paola M (2006). Chronic rhinoviral infection in lung transplant recipients. American journal of respiratory and critical care medicine, 174(12), pp. 1392-9. New York, N.Y.: American Lung Association 10.1164/rccm.200604-489OC

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RATIONALE: Lung transplant recipients are particularly at risk of complications from rhinovirus, the most frequent respiratory virus circulating in the community. OBJECTIVES: To determine whether lung transplant recipients can be chronically infected by rhinovirus and the potential clinical impact. METHODS: We first identified an index case, in which rhinovirus was isolated repeatedly, and conducted detailed molecular analysis to determine whether this was related to a unique strain or to re-infection episodes. Transbronchial biopsies were used to assess the presence of rhinovirus in the lung parenchyma. The incidence of chronic rhinoviral infections and potential clinical impact was assessed prospectively in a cohort of 68 lung transplant recipients during 19 mo by screening of bronchoalveolar lavages. MEASUREMENTS AND MAIN RESULTS: We describe 3 lung transplant recipients with graft dysfunctions in whom rhinovirus was identified by reverse transcriptase-polymerase chain reaction in upper and lower respiratory specimens over a 12-mo period. In two cases, rhinovirus was repeatedly isolated in culture. The persistence of a unique strain in each case was confirmed by sequence analysis of the 5'NCR and VP1 gene. In the index case, rhinovirus was detected in the lower respiratory parenchyma. In the cohort of lung transplant recipients, rhinoviral infections were documented in bronchoalveolar lavage specimens of 10 recipients, and 2 presented with a persistent infection. CONCLUSIONS: Rhinoviral infection can be persistent in lung transplant recipients with graft dysfunction, and the virus can be detected in the lung parenchyma. Given the potential clinical impact, chronic rhinoviral infection needs to be considered in lung transplant recipients.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology
UniBE Contributor:	Nicod, Laurent
ISSN:	1073-449X
ISBN:	17008640
Publisher:	American Lung Association
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:48
Last Modified:	05 Dec 2022 14:15
Publisher DOI:	10.1164/rccm.200604-489OC
PubMed ID:	17008640
Web of Science ID:	000242889400017
URI:	https://boris.unibe.ch/id/eprint/20227 (FactScience: 3406)