On the postnatal development of the striate cortex (V1) in the tree shrew (Tupaia belangeri)

Drenhaus, Ulrich; Rager, Günter; Eggli, Peter; Kretz, Robert (2006). On the postnatal development of the striate cortex (V1) in the tree shrew (Tupaia belangeri). European journal of neuroscience, 24(2), pp. 479-90. Oxford: Blackwell Science 10.1111/j.1460-9568.2006.04916.x

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Histological serial sections, three-dimensional reconstructions and morphometry served to study the postnatal development of V1 in tree shrews. The main objectives were to evaluate the expansion of V1, the implications of its growth on the occipital cortex and, vice versa, the effects of the expanding neocortex on the topography of V1. The future V1 was identified on postnatal day 1 by its granular layer IV, covering the superior surface of the occipital cortices including the poles. A subdivision of layer IV, distinctive for the binocular part, was evident in the central region. V1 expanded continuously with age into all directions succeeded by the maturation of layering. The monocular part was recognized from day 15 onward, after the binocular part had reached its medial border. In reference to the retinotopic map of V1, regions emerged in a coherent temporo-spatial sequence delineating the retinal topography in a central to peripheral gradient beginning with the visual streak representation. The growth of V1 was greatest until tree shrews open their eyes, culminated during adolescence, and completed after a subsequent decrease in the young adult. Simultaneous expansion of the neocortex induced a shifting of V1. Translation and elongation of V1 entailed that the occipital cortex covered the superior colliculi along with a downward rotation of the poles. The enlargement of the occipital part of the hemispheres was in addition associated with the formation of a small occipital horn in the lateral ventricles, indicating an incipient 'true' occipital lobe harbouring mainly cortices involved in visual functions.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy

UniBE Contributor:

Eggli, Peter

ISSN:

0953-816X

ISBN:

16836641

Publisher:

Blackwell Science

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:49

Last Modified:

17 Mar 2015 21:49

Publisher DOI:

10.1111/j.1460-9568.2006.04916.x

PubMed ID:

16836641

Web of Science ID:

000239152900015

URI:

https://boris.unibe.ch/id/eprint/20364 (FactScience: 3652)

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