Uveitic glaucoma and Rosai-Dorfman disease (sinus histiocytosis)

MacLaren, Robert E; Hundal, Kulwinder S; Trittibach, Peter; Bloom, Philip A (2006). Uveitic glaucoma and Rosai-Dorfman disease (sinus histiocytosis). Ocular immunology and inflammation, 14(5), pp. 305-7. New York, N.Y.: Informa Healthcare 10.1080/09273940600878829

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PURPOSE: To report a novel association of uveitic glaucoma with Rosai-Dorfman disease. METHODS: Case report. RESULTS: A 67-year-old Caucasian woman presented with a chronic bilateral granulomatous uveitis which did not respond to conventional topical steroid therapy. She also had raised intraocular pressures, glaucomatous optic disc changes and diffuse nodular fibrous skin lesions. Subsequent skin biopsy immuno-cytochemistry showed S-100 staining, consistent with Rosai-Dorfman disease. The uveitis and glaucoma were highly resistant to standard medical treatments, but completely resolved together with the systemic features of the disease after six months. CONCLUSIONS: Rosai-Dorfman disease has not previously been reported to cause uveitic glaucoma and should be considered in non-responsive cases presenting with a rash. The disease is entirely self-limiting and early diagnosis may therefore avoid unnecessary trabeculectomy and/or systemic immune suppression.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Trittibach, Peter

ISSN:

0927-3948

ISBN:

17056465

Publisher:

Informa Healthcare

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:49

Last Modified:

17 Mar 2015 21:50

Publisher DOI:

10.1080/09273940600878829

PubMed ID:

17056465

Web of Science ID:

000241435500007

URI:

https://boris.unibe.ch/id/eprint/20453 (FactScience: 3751)

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