Grey-matter abnormalities in boys with Tourette syndrome: magnetic resonance imaging study using optimised voxel-based morphometry

Ludolph, Andrea G; Juengling, Freimut D; Libal, Gerhard; Ludolph, Albert C; Fegert, Jörg M; Kassubek, Jan (2006). Grey-matter abnormalities in boys with Tourette syndrome: magnetic resonance imaging study using optimised voxel-based morphometry. British journal of psychiatry, 188, pp. 484-485. London: Royal College of Psychiatrists 10.1192/bjp.bp.105.008813

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The genesis of Tourette syndrome is still unknown, but a core role for the pathways of cortico-striatal-thalamic-cortical circuitry (CSTC) is supposed. Volume-rendering magnetic resonance imaging data-sets were analysed in 14 boys with Tourette syndrome and 15 age-matched controls using optimised voxel-based morphometry. Locally increased grey-matter volumes (corrected P < 0.001) were found bilaterally in the ventral putamen. Regional decreases in grey matter were observed in the left hippocampal gyrus. This unbiased analysis confirmed an association between striatal abnormalities and Tourette syndrome, and the hippocampal volume alterations indicate an involvement of temporolimbic pathways of the CSTC in the syndrome.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine
UniBE Contributor:	Jüngling, Freimut
ISSN:	0007-1250
ISBN:	16648537
Publisher:	Royal College of Psychiatrists
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:49
Last Modified:	05 Dec 2022 14:15
Publisher DOI:	10.1192/bjp.bp.105.008813
PubMed ID:	16648537
Web of Science ID:	000237501900015
URI:	https://boris.unibe.ch/id/eprint/20642 (FactScience: 4317)