Grey-matter abnormalities in boys with Tourette syndrome: magnetic resonance imaging study using optimised voxel-based morphometry

Ludolph, Andrea G; Juengling, Freimut D; Libal, Gerhard; Ludolph, Albert C; Fegert, Jörg M; Kassubek, Jan (2006). Grey-matter abnormalities in boys with Tourette syndrome: magnetic resonance imaging study using optimised voxel-based morphometry. British journal of psychiatry, 188, pp. 484-485. London: Royal College of Psychiatrists 10.1192/bjp.bp.105.008813

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The genesis of Tourette syndrome is still unknown, but a core role for the pathways of cortico-striatal-thalamic-cortical circuitry (CSTC) is supposed. Volume-rendering magnetic resonance imaging data-sets were analysed in 14 boys with Tourette syndrome and 15 age-matched controls using optimised voxel-based morphometry. Locally increased grey-matter volumes (corrected P < 0.001) were found bilaterally in the ventral putamen. Regional decreases in grey matter were observed in the left hippocampal gyrus. This unbiased analysis confirmed an association between striatal abnormalities and Tourette syndrome, and the hippocampal volume alterations indicate an involvement of temporolimbic pathways of the CSTC in the syndrome.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine

UniBE Contributor:

Jüngling, Freimut

ISSN:

0007-1250

ISBN:

16648537

Publisher:

Royal College of Psychiatrists

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:49

Last Modified:

08 Jun 2016 10:40

Publisher DOI:

10.1192/bjp.bp.105.008813

PubMed ID:

16648537

Web of Science ID:

000237501900015

URI:

https://boris.unibe.ch/id/eprint/20642 (FactScience: 4317)

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